Detailed Information
Cited 7 time in 
Cited 8 time in 
Cited 8 time in
Metadata Downloads
Dehydroevodiamine·HCl improves stress-induced memory impairments and depression like behavior in rats
- Authors
- Hee Jin Kim; Shin K.Y.; Chang K.-A.; Ahn S.; Choi H.S.; Kim H.-S.; Suh Y.-H.
- Issue Date
- Feb-2014
- Publisher
- Korean Physiological Soc. and Korean Soc. of Pharmacology
- Keywords
- Depression; DHED; Fluoxetine; Memory; Stress
- Citation
- Korean Journal of Physiology and Pharmacology, v.18, no.1, pp.55 - 59
- Journal Title
- Korean Journal of Physiology and Pharmacology
- Volume
- 18
- Number
- 1
- Start Page
- 55
- End Page
- 59
- ISSN
- 1226-4512
- Abstract
- Dehydroevodiamine·HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.