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The Therapeutic Effects of Human Adipose-Derived Stem Cells in Alzheimer's Disease Mouse Models

Authors
Chang, Keun-A.Kim, Hee JinJoo, YuyoungHa, SungjiSuh, Yoo-Hun
Issue Date
Feb-2014
Publisher
KARGER
Keywords
Alzheimer' s disease; Adipose-derived stem cells
Citation
NEURODEGENERATIVE DISEASES, v.13, no.2-3, pp.99 - 102
Journal Title
NEURODEGENERATIVE DISEASES
Volume
13
Number
2-3
Start Page
99
End Page
102
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/959
DOI
10.1159/000355261
ISSN
1660-2854
Abstract
Alzheimer's disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD. Adipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency and their ability to differentiate into multiple tissue types and have immune modulatory properties similar to those of MSCs from other origins. Because of their biological properties, ASCs can be considered for cell therapy and neuroregeneration. Our recent results clearly showed the therapeutic potential of these cells after transplantation into Tg2576 mice (an AD mouse model). Intravenously or intracerebrally transplanted human ASCs (hASCs) greatly improved the memory impairment and the neuropathology, suggesting that hASCs have a high therapeutic potential for AD. (C) 2013 S. Karger AG, Basel
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