Detailed Information

Cited 1 time in webofscience Cited 0 time in scopus
Metadata Downloads

SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion.

Full metadata record
DC Field Value Language
dc.contributor.authorAn, Sunho-
dc.contributor.authorVo, Tam Thuy Lu-
dc.contributor.authorSon, Taekwon-
dc.contributor.authorChoi, Hoon-
dc.contributor.authorKim, Jinyoung-
dc.contributor.authorLee, Juyeon-
dc.contributor.authorKim, Byung Hoon-
dc.contributor.authorChoe, Misun-
dc.contributor.authorHa, Eunyoung-
dc.contributor.authorSurh, Young-Joon-
dc.contributor.authorKim, Kyu-Won-
dc.contributor.authorSeo, Ji Hae-
dc.date.accessioned2023-09-19T04:23:54Z-
dc.date.available2023-09-19T04:23:54Z-
dc.date.issued2023-04-
dc.identifier.issn1226-3613-
dc.identifier.issn2092-6413-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/975-
dc.description.abstractHuman sterile α motif and HD domain-containing protein 1 (SAMHD1) has deoxyribonucleoside triphosphohydrolase (dNTPase) activity that allows it to defend against human immunodeficiency virus type I (HIV-1) infections and regulate the cell cycle. Although SAMHD1 mutations have been identified in various cancer types, their role in cancer is unclear. Here, we aimed to investigate the oncogenic role of SAMHD1 in human clear cell renal cell carcinoma (ccRCC), particularly as a core molecule promoting cancer cell migration. We found that SAMHD1 participated in endocytosis and lamellipodia formation. Mechanistically, SAMHD1 contributed to the formation of the endosomal complex by binding to cortactin. Thereafter, SAMHD1-stimulated endosomal focal adhesion kinase (FAK) signaling activated Rac1, which promoted lamellipodia formation on the plasma membrane and enhanced the motility of ccRCC cells. Finally, we observed a strong correlation between SAMHD1 expression and the activation of FAK and cortactin in tumor tissues obtained from patients with ccRCC. In brief, these findings reveal that SAMHD1 is an oncogene that plays a pivotal role in ccRCC cell migration through the endosomal FAK-Rac1 signaling pathway. © 2023. The Author(s).-
dc.format.extent15-
dc.language영어-
dc.language.isoENG-
dc.publisherSPRINGERNATURE-
dc.titleSAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion.-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1038/s12276-023-00961-x-
dc.identifier.wosid001066758000010-
dc.identifier.bibliographicCitationExperimental & molecular medicine, v.55, no.4, pp 779 - 793-
dc.citation.titleExperimental & molecular medicine-
dc.citation.volume55-
dc.citation.number4-
dc.citation.startPage779-
dc.citation.endPage793-
dc.type.docTypeJournal Article;Research Support, Non-U.S. Gov't-
dc.identifier.kciidART002952736-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusRAC1 ACTIVATION-
dc.subject.keywordPlusCANCER-CELLS-
dc.subject.keywordPlusSAMHD1-
dc.subject.keywordPlusADHESION-
dc.subject.keywordPlusCORTACTIN-
dc.subject.keywordPlusINTEGRIN-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusRESTRICTION-
dc.subject.keywordPlusRHO-
dc.subject.keywordPlusALPHA-V-BETA-3-
Files in This Item
Appears in
Collections
연구전략실 > 한국뇌은행 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Son, Tae kwon photo

Son, Tae kwon
연구전략실 (한국뇌은행)
Read more

Altmetrics

Total Views & Downloads

BROWSE