독활의 항혈소판 및 항산화 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양선아 | - |
dc.contributor.author | 임남경 | - |
dc.contributor.author | 지광환 | - |
dc.contributor.author | 이인선 | - |
dc.date.available | 2020-10-20T05:42:55Z | - |
dc.date.created | 2020-06-16 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1225-9918 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/17991 | - |
dc.description.abstract | The dried roots of Aralia continentalis Kitagawa is known to have the potential for anti-inflammation and anti-rheumatic, but their effects on thrombosis are not clear. In this study, we evaluated the anti-platelet and antioxidative activities of A. continentalis Kitagawa. Methanol extract and its various fractions of A. continentalis Kitagawa inhibited ADP-induced platelet aggregation, and EtOAc fraction showed strongest inhibition in a concentration-dependent manner with a IC50 value of 217.7 μg/ml. Moreover, the EtOAc fraction contained 77.7% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 43.1% of 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging activity at 0.1 mg/ml. In addition, the methanol and EtOAc fraction dose-dependently inhibited thrombin-stimulated platelet adhesion to collagen or fibrinogen. Collectively, these results suggest that the polyphenol-rich EtOAc fraction from A. continentalis Kitagawa can reduce platelet hyperactivation by scavenging free radicals. Thus, the EtOAc fraction of A. continentalis Kitagawa is a potential source for inhibition of platelet-dependent thrombosis. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한국생명과학회 | - |
dc.title | 독활의 항혈소판 및 항산화 효과 | - |
dc.title.alternative | Effects of Aralia continentalis Kitagawa on Antiplatelet and Antioxidative Activities | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 지광환 | - |
dc.identifier.bibliographicCitation | 생명과학회지, v.18, no.3, pp.357 - 362 | - |
dc.relation.isPartOf | 생명과학회지 | - |
dc.citation.title | 생명과학회지 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 357 | - |
dc.citation.endPage | 362 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001232348 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Aralia continentalis Kitagawa | - |
dc.subject.keywordAuthor | platelet aggregation | - |
dc.subject.keywordAuthor | platelet adhesion | - |
dc.subject.keywordAuthor | antioxidant | - |
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