Gold Nanocage-Incorporated Poly(epsilon-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy
DC Field | Value | Language |
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dc.contributor.author | Park, Ju Hyang | - |
dc.contributor.author | Seo, Hojun | - |
dc.contributor.author | Kim, Da In | - |
dc.contributor.author | Choi, Ji Hyun | - |
dc.contributor.author | Son, Jin Ho | - |
dc.contributor.author | Kim, Jongbok | - |
dc.contributor.author | Moon, Geon Dae | - |
dc.contributor.author | Hyun, Dong Choon | - |
dc.date.available | 2020-04-24T10:25:16Z | - |
dc.date.created | 2020-03-31 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/199 | - |
dc.description.abstract | This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(epsilon-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on-off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | CHANGEABLE FATTY-ACID | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | INDOCYANINE GREEN | - |
dc.subject | PHASE-TRANSFER | - |
dc.subject | NIR LIGHT | - |
dc.subject | NANOPARTICLES | - |
dc.subject | NANOFIBERS | - |
dc.title | Gold Nanocage-Incorporated Poly(epsilon-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jongbok | - |
dc.identifier.doi | 10.3390/pharmaceutics11020060 | - |
dc.identifier.scopusid | 2-s2.0-85063191771 | - |
dc.identifier.wosid | 000460799900012 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, v.11, no.2 | - |
dc.relation.isPartOf | PHARMACEUTICS | - |
dc.citation.title | PHARMACEUTICS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CHANGEABLE FATTY-ACID | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | INDOCYANINE GREEN | - |
dc.subject.keywordPlus | PHASE-TRANSFER | - |
dc.subject.keywordPlus | NIR LIGHT | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | NANOFIBERS | - |
dc.subject.keywordAuthor | PCL | - |
dc.subject.keywordAuthor | electrospinning | - |
dc.subject.keywordAuthor | combination therapy | - |
dc.subject.keywordAuthor | photothermal therapy | - |
dc.subject.keywordAuthor | NIR-triggered drug release | - |
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