The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Jang, Eue-Soon | - |
dc.contributor.author | Shin, June-Ho | - |
dc.contributor.author | Ren, Gang | - |
dc.contributor.author | Park, Mi-Jin | - |
dc.contributor.author | Cheng, Kai | - |
dc.contributor.author | Chen, Xiaoyuan | - |
dc.contributor.author | Wu, Joseph C. | - |
dc.contributor.author | Sunwoo, John B. | - |
dc.contributor.author | Cheng, Zhen | - |
dc.date.accessioned | 2021-11-05T02:48:01Z | - |
dc.date.available | 2021-11-05T02:48:01Z | - |
dc.date.created | 2020-06-16 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/20149 | - |
dc.description.abstract | The present work demonstrates that Cy5.5 conjugated Fe3O4/SiO2 core/shell nanoparticles could allow us to control movement of human natural killer cells (NK-92MI) by an external magnetic field. Required concentration of the nanoparticles for the cell manipulation is as low as similar to 20 mu g Fe/mL. However, the relative ratio of the nanoparticles loaded NK-92MI cells infiltrated into the target tumor site is enhanced by 17-fold by applying magnetic field and their killing activity is still maintained as same as the NK-92MI cells without the nanoparticles. This approach allows us to open alternative clinical treatment with reduced toxicity of the nanoparticles and enhanced infiltration of immunology to the target site. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | IRON-OXIDE NANOPARTICLES | - |
dc.subject | REVERSE MICROEMULSION METHOD | - |
dc.subject | QUANTUM DOTS | - |
dc.subject | SILICA NANOPARTICLES | - |
dc.subject | SIZE | - |
dc.subject | EDUCATION | - |
dc.subject | DELIVERY | - |
dc.subject | SPHERES | - |
dc.subject | GROWTH | - |
dc.subject | SHELL | - |
dc.title | The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Eue-Soon | - |
dc.identifier.doi | 10.1016/j.biomaterials.2012.04.041 | - |
dc.identifier.wosid | 000305366500010 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.33, no.22, pp.5584 - 5592 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 5584 | - |
dc.citation.endPage | 5592 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | IRON-OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | REVERSE MICROEMULSION METHOD | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | EDUCATION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | SPHERES | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | SHELL | - |
dc.subject.keywordAuthor | Fe3O4/SiO2 core/shell nanoparticles | - |
dc.subject.keywordAuthor | Multifunctional nanoparticles | - |
dc.subject.keywordAuthor | Magnetic field guided cell control | - |
dc.subject.keywordAuthor | Natural killer cells | - |
dc.subject.keywordAuthor | Tumor killing activity | - |
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