Biodegradable silicon nanoneedles for ocular drug delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Woohyun | - |
dc.contributor.author | Van Phuc Nguyen | - |
dc.contributor.author | Jeon, Yale | - |
dc.contributor.author | Kim, Bongjoong | - |
dc.contributor.author | Li, Yanxiu | - |
dc.contributor.author | Yi, Jonghun | - |
dc.contributor.author | Kim, Hyungjun | - |
dc.contributor.author | Leem, Jung Woo | - |
dc.contributor.author | Kim, Young L. | - |
dc.contributor.author | Kim, Dong Rip | - |
dc.contributor.author | Paulus, Yannis M. | - |
dc.contributor.author | Lee, Chi Hwan | - |
dc.date.accessioned | 2022-05-17T02:05:46Z | - |
dc.date.available | 2022-05-17T02:05:46Z | - |
dc.date.created | 2022-05-17 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/21095 | - |
dc.description.abstract | Ocular drug delivery remains a grand challenge due to the complex structure of the eye. Here, we introduce a unique platform of ocular drug delivery through the integration of silicon nanoneedles with a tear-soluble contact lens. The silicon nanoneedles can penetrate into the cornea in a minimally invasive manner and then undergo gradual degradation over the course of months, enabling painless and long-term sustained delivery of ocular drugs. The tear-soluble contact lens can fit a variety of corneal sizes and then quickly dissolve in tear fluid within a minute, enabling an initial burst release of anti-inflammatory drugs. We demonstrated the utility of this platform in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a notable side effect over current standard therapies. This platform could also be useful in treating other chronic ocular diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Biodegradable silicon nanoneedles for ocular drug delivery | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyungjun | - |
dc.identifier.doi | 10.1126/sciadv.abn1772 | - |
dc.identifier.wosid | 000778886800030 | - |
dc.identifier.bibliographicCitation | SCIENCE ADVANCES, v.8, no.13 | - |
dc.relation.isPartOf | SCIENCE ADVANCES | - |
dc.citation.title | SCIENCE ADVANCES | - |
dc.citation.volume | 8 | - |
dc.citation.number | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | RABBIT | - |
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