Multifunctional chitosan-bimetallic nanocarrier deliver 5-fluorouracil for enhanced treatment of pancreatic and triple-negative breast cancer
DC Field | Value | Language |
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dc.contributor.author | Saravanakumar, Kandasamy | - |
dc.contributor.author | Sathiyaseelan, Anbazhagan | - |
dc.contributor.author | Manivasagan, Panchanathan | - |
dc.contributor.author | Zhang, Xin | - |
dc.contributor.author | Jeong, Myeong Seon | - |
dc.contributor.author | Jang, Eue-Soon | - |
dc.contributor.author | Wang, Myeong-Hyeon | - |
dc.date.accessioned | 2024-02-19T01:00:21Z | - |
dc.date.available | 2024-02-19T01:00:21Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.issn | 1879-0003 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/26617 | - |
dc.description.abstract | This work aimed to prepare multifunctional aptamer-conjugated, photothermally responsive 5-fluorouracil (5fu)-loaded chitosan-bimetallic (Au/Pd) nanoparticles (APT-CS-5fu-Au/Pd NPs) for improved cytotoxicity in two cancer cell lines (PANC-1 and MDA-MD 231). The CS-5fu-Au/Pd NPs were polydispersed with a size of 34.43 +/- 1.59 nm. FTIR analysis indicated the presence of CS, 5fu in CS-5fu-Au/Pd NPs. The 2 theta degrees in CS-5fu-Au/Pd NPs accounted for CS and Au/Pd. Additionally, AGE revealed the conjugation of APT in CS-5fu-Au/Pd NPs. The APT-CS-5fu-Au/Pd NPs (180 mu g/mL) with NIR treatment increased the temperature to >50 degrees C. The optimized 5fu input was 0.075 % in CS-5fu-Au/Pd NPs, exhibiting a hydrodynamic size of 112.96 +/- 17.23 nm, DEE of 64.2 +/- 3.77 %, and DLE of 11.1 +/- 0.65 %. A higher level of 5fu release (69.8 +/- 2.78 %) was observed under pH 5.4 at 74 h. In conclusion, NIR-APT-CS-5fu-Au/Pd NPs did not cause toxicity to RBC and Egg CAM, but increased cytotoxicity in MDA-MB 231 and PANC-1 cells by triggering oxidative stress-mediated cell death. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER | - |
dc.title | Multifunctional chitosan-bimetallic nanocarrier deliver 5-fluorouracil for enhanced treatment of pancreatic and triple-negative breast cancer | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2023.129165 | - |
dc.identifier.scopusid | 2-s2.0-85181918304 | - |
dc.identifier.wosid | 001156822300001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.259 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
dc.citation.volume | 259 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | PH | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | NUCLEOLIN | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | PD | - |
dc.subject.keywordAuthor | Au/Pd nanoparticles | - |
dc.subject.keywordAuthor | 5-Fluorouracil | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Aptamer | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
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