TNF-α/IFN-γ로 자극된 HaCaT 및 IgE로 감작된 RBL-2H3 세포에서 닥나무 가지 추출물의 알러지 염증반응 억제 효과Inhibitory effects of Broussonetia kazinoki twig extract on allergic inflammatory reactions in TNF-α/IFN-γ-stimulated HaCaT and IgE-sensitized RBL-2H3 cells
- Other Titles
- Inhibitory effects of Broussonetia kazinoki twig extract on allergic inflammatory reactions in TNF-α/IFN-γ-stimulated HaCaT and IgE-sensitized RBL-2H3 cells
- Authors
- 배원빈; 김은혜; 김민주; 양선아
- Issue Date
- Apr-2024
- Publisher
- 한국식품저장유통학회
- Keywords
- Broussonetia kazinoki; anti-inflammation; anti-allergy; HaCaT keratinocytes; RBL-2H3 cells
- Citation
- Food Science and Preservation, v.31, no.2, pp 307 - 314
- Pages
- 8
- Journal Title
- Food Science and Preservation
- Volume
- 31
- Number
- 2
- Start Page
- 307
- End Page
- 314
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/28689
- DOI
- 10.11002/fsp.2024.31.2.307
- ISSN
- 3022-5477
3022-5485
- Abstract
- Broussonetia kazinoki twig extract (BKT) is recognized for its antioxidant and anti-cancer effects and natural whitening properties. So, it is used as a raw material for cosmetics. B. kazinoki twig is also an edible raw material. B. kazinoki has been used in Asia for paper production and oriental medicine, has anti-diabetic effects, and contains various flavonoids and alkaloids. In this study, to evaluate the efficacy of BKT on allergic skin inflammatory responses, we investigated its effects on factors related to skin inflammation in HaCaT keratinocytes and allergic responses in RBL-2H3 cells. There was no cytotoxicity of the 70% ethanol extract against HaCaT and RBL-2H3 cells. In HaCaT cells, stimulation with tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) increased the production of several chemokines, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC), and regulated on activation, normal T cell expressed and secreted (RANTES). However, it was observed that this elevation was notably mitigated in a concentration-dependent manner upon treatment with BKT. Furthermore, BKT treatment demonstrated a significant reduction of β-hexosaminidase and inflammatory cytokines TNF-α and IL-4 in IgE-sensitized RBL-2H3 cells. Thus, it is expected that BKT can be used as a natural cosmetic and food ingredient that effectively suppresses allergic inflammatory reactions
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