https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/873 2026-04-04T21:04:59Z 2026-04-04T21:04:59Z Shin, Hwang Sik Park, Yoon Hyung Lee, Sung Soo Cho, Yong Jin Kwon, Jun Tack Chang, Youngs Lee, Mee-Ri Hwangbo, Young https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26434 2025-11-22T04:05:27Z 2024-05-01T00:00:00Z

Title: Development of a Risk Score to Predict Short-term Smoking Relapse Following an Inpatient Smoking Cessation Intervention Authors: Shin, Hwang Sik; Park, Yoon Hyung; Lee, Sung Soo; Cho, Yong Jin; Kwon, Jun Tack; Chang, Youngs; Lee, Mee-Ri; Hwangbo, Young Abstract: This study aimed to investigate the factors affecting smoking relapse and to develop predictive models among Korean national 5-day smoking cessation program participants. The subjects were 518 smokers and follow-up was continued for 6 months after discharge. A predictive logistic model and risk score were developed from the multivariate logistic models and compared using the area under the receiver operating characteristic curve (area under the curve [AUC]). The smoking relapse rate within 6 months after program participation was 38.4%. The AUCs of the logistic regression model and risk score model were similar (odds ratio [OR] = 0.69, 95% confidence interval [CI] [0.64, 0.75]; 0.69, 95% CI [0.63, 0.74], respectively) in the development data set, and those of the risk score model were similar between the development and validation data sets (OR = 0.68, 95% CI [0.59, 0.77]). The risk score used by the six risk factors could predict smoking relapse among participants who attended a 5-day inpatient smoking cessation program.

2024-05-01T00:00:00Z Chang, Jun Young Lee, Ji Sung Kim, Wook-Joo Kwon, Jee Hyun Kim, Beom Joon Kim, Joon-Tae Lee, Jun Cha, Jae Kwan Kim, Dae-Hyun Cho, Yong-Jin Hong, Keun-Sik Lee, Soo Joo Park, Jong-Moo Kang, Kyusik Lee, Byung-Chul Yu, Kyung-Ho Lee, Sang-Hwa Kim, Chulho Park, Kwang-Yeol Kim, Dong-Eog Lee, Kyungbok Park, Tai Hwan Choi, Jay Chol Shin, Dong-Ick Sohn, Sung-Il Bae, Hee-Joon Han, Moon-Ku https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26344 2025-11-22T04:04:29Z 2024-04-01T00:00:00Z

Title: Efficacy of Endovascular Thrombectomy in Acute Basilar Artery Occlusion with Low PC-ASPECTS: A Nationwide Prospective Registry-Based Study Authors: Chang, Jun Young; Lee, Ji Sung; Kim, Wook-Joo; Kwon, Jee Hyun; Kim, Beom Joon; Kim, Joon-Tae; Lee, Jun; Cha, Jae Kwan; Kim, Dae-Hyun; Cho, Yong-Jin; Hong, Keun-Sik; Lee, Soo Joo; Park, Jong-Moo; Kang, Kyusik; Lee, Byung-Chul; Yu, Kyung-Ho; Lee, Sang-Hwa; Kim, Chulho; Park, Kwang-Yeol; Kim, Dong-Eog; Lee, Kyungbok; Park, Tai Hwan; Choi, Jay Chol; Shin, Dong-Ick; Sohn, Sung-Il; Bae, Hee-Joon; Han, Moon-Ku Abstract: Objective: We evaluated the efficacy of endovascular thrombectomy (EVT) on the functional outcome of patients with acute basilar artery occlusion and low posterior circulation acute stroke prognosis early computed tomography score (PC-ASPECTS). Methods: We identified patients with acute ischemic stroke due to basilar artery occlusion and PC-ASPECTS of 6 or less, presenting within 24 h between August 2008 and April 2022. The primary outcome was a favorable functional outcome, defined as a modified Rankin Scale (mRS) score of 0-3 at 90 days. The secondary outcomes included an mRS score of 0-2, a favorable shift in the ordinal mRS scale, the occurrence of symptomatic intracranial hemorrhage (sICH), and mortality at 90 days. We compared the outcome of patients treated with EVT and those without EVT, using the inverse probability of treatment weighting methods. Results: Out of 566 patients, 55.5% received EVT. In the EVT group, 106 (33.8%) achieved favorable outcomes, compared to 56 patients (22.2%) in the conservative group. EVT significantly increased the likelihood of achieving a favorable outcome compared to conservative treatment (relative risk [RR] 1.39, 95% confidence interval [CI], 1.11-1.74, p = 0.004). EVT was associated with a favorable shift in the mRS (RR 1.85, 95% CI, 1.49-2.29, p < 0.001) and reduced mortality without an increase in the risk of sICH. It did not have an impact on achieving an mRS score of 0-2. Interpretation: Patients with acute basilar artery occlusion and a PC-ASPECTS of 6 or less might benefit from EVT without an increasing sICH. ANN NEUROL 2024

2024-04-01T00:00:00Z Lee, Minwoo Lee, Byung-Chul Yu, Kyung-Ho Oh, Mi-Sun Kim, Beom Joon Kim, Jun Yup Kang, Jihoon Lee, Keon-Joo Kim, Do Yeon Park, Jong-Moo Kang, Kyusik Park, Tai Hwan Lee, Kyung Bok Hong, Keun-Sik Park, Hong-Kyun Cho, Yong-Jin Kim, Dong-Eog Lee, Soo Joo Kim, Jae Guk Lee, Jun Cha, Jae-Kwan Kim, Dae-Hyun Kim, Joon-Tae Choi, Kang-Ho Choi, Jay Chol Sohn, Sung-il Hong, Jeong-Ho Lee, Sang-hwa Kim, Chulho Shin, Dong-Ick Yum, Kyu Sun Lee, Juneyoung Lee, Ji Sung Gorelick, Philip B. Bae, Hee-Joon https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26332 2025-11-22T04:04:34Z 2024-03-01T00:00:00Z

Title: Secular Trends in Outcomes and Impact of Novel Oral Anticoagulants in Atrial Fibrillation-Related Acute Ischemic Stroke Authors: Lee, Minwoo; Lee, Byung-Chul; Yu, Kyung-Ho; Oh, Mi-Sun; Kim, Beom Joon; Kim, Jun Yup; Kang, Jihoon; Lee, Keon-Joo; Kim, Do Yeon; Park, Jong-Moo; Kang, Kyusik; Park, Tai Hwan; Lee, Kyung Bok; Hong, Keun-Sik; Park, Hong-Kyun; Cho, Yong-Jin; Kim, Dong-Eog; Lee, Soo Joo; Kim, Jae Guk; Lee, Jun; Cha, Jae-Kwan; Kim, Dae-Hyun; Kim, Joon-Tae; Choi, Kang-Ho; Choi, Jay Chol; Sohn, Sung-il; Hong, Jeong-Ho; Lee, Sang-hwa; Kim, Chulho; Shin, Dong-Ick; Yum, Kyu Sun; Lee, Juneyoung; Lee, Ji Sung; Gorelick, Philip B.; Bae, Hee-Joon Abstract: BACKGROUND:Novel oral anticoagulants (NOACs) are currently recommended for the secondary prevention of stroke in patients with acute ischemic stroke (AIS) accompanied by atrial fibrillation (AF). However, the impact of NOACs on clinical outcomes in real-world practice remains ambiguous. This study analyzes the trend of clinical events in patients with AF-related AIS and determines how much the introduction of NOACs has mediated this trend.METHODS:We identified patients with AIS and AF between January 2011 and December 2019 using a multicenter stroke registry. Annual rates of NOAC prescriptions and clinical events within 1 year were evaluated. The primary outcome was a composite of recurrent stroke, myocardial infarction, and all-cause mortality. To assess the mediation effect of NOACs on the relationship between the calendar year and these outcomes, we used natural effect models and conducted exposure-mediator, exposure-outcome, and mediator-outcome analyses using multivariable regression models or accelerated failure time models, adjusting for potential confounders.RESULTS:Among the 12 977 patients with AF-related AIS, 12 500 (average age: 74.4 years; 51.3% male) were analyzed after excluding cases of valvular AF. Between 2011 and 2019, there was a significant decrease in the 1-year incidence of the primary composite outcome from 28.3% to 21.7%, while the NOAC prescription rate increased from 0% to 75.6%. A 1-year increase in the calendar year was independently associated with delayed occurrence of the primary outcome (adjusted time ratio, 1.10 [95% CI, 1.07-1.14]) and increased NOAC prescription (adjusted odds ratio, 2.20 [95% CI, 2.14-2.27]). Increased NOAC prescription was associated with delayed occurrence of the primary outcome (adjusted time ratio, 3.82 [95% CI, 3.17 to 4.61]). Upon controlling for NOAC prescription (mediator), the calendar year no longer influenced the primary outcome (adjusted time ratio, 0.97 [95% CI, 0.94-1.00]). This suggests that NOAC prescription mediates the association between the calendar year and the primary outcome.CONCLUSIONS:Our study highlights a temporal reduction in major clinical events or death in Korean patients with AF-related AIS, mediated by increased NOAC prescription, emphasizing NOAC use in this population.

2024-03-01T00:00:00Z Lee, Jong Seung Hong, Seung-ho Sun, Hwa Yeon Jin, Hyungseung Yu, Byung Yeon Cho, Yong-jin Chang, Jin young Yoo, Byung Wook https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22410 2025-11-22T02:05:34Z 2023-12-01T00:00:00Z

Title: The efficacy and safety of tadalafil in the management of erectile dysfunction with diabetes and blood circulation issues Authors: Lee, Jong Seung; Hong, Seung-ho; Sun, Hwa Yeon; Jin, Hyungseung; Yu, Byung Yeon; Cho, Yong-jin; Chang, Jin young; Yoo, Byung Wook Abstract: Background Erectile dysfunction (ED) is a common diabetes-related complication. Materials and methods This study examined the effect of daily low-dose tadalafil (5 mg) on patients' quality of life (including that of sex life) and blood circulation. Erectile dysfunction questionnaires were administered to 20 patients with type 2 diabetes (T2DM) and ED. The safety and efficacy of tadalafil were evaluated using laboratory tests, and the effect on blood circulation was measured through nail fold capillaroscopy. Results Daily tadalafil use by patients with T2DM and ED showed a statistically significant increase in the erectile reliability score from of 1.15 to 3.20 (p < .00012). Capillary blood circulation improvement tests showed a statistically significant increase in apical limb width from 13.1 to 14.64 mu m (p = .04829) and flow from 9035 to 11946 mu m(3)/s (p = .04405). Although not significant, increased capillary width and speed (rate of blood flow) confirmed improved blood circulation. There were no significant changes in the cardiac indicators (troponin, prostate-specific antigen, or electrocardiogram tests) before and after tadalafil administration, supporting the safety of its low-dose daily administration. Conclusions A small dose of daily tadalafil was shown to safely improve erectile dysfunction and peripheral blood flow in patients with T2DM, in which peripheral arterial diseases should not be considered separately but rather as complex entities.

2023-12-01T00:00:00Z