https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/1017 2026-04-04T01:13:00Z https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/27999 Title: Aetiology of chronic liver disease is a valuable factor for stratifying adverse outcomes of acute decompensation: prospective observational study Authors: Kim, Jung Hee; Kim, Sung-Eun; Song, Do Seon; Kim, Hee Yeon; Yoon, Eileen L.; Park, Ji Won; Kim, Tae Hyung; Jung, Young-Kul; Suk, Ki Tae; Yim, Hyung Joon; Kwon, Jung Hyun; Lee, Sung Won; Kang, Seong Hee; Kim, Moon Young; Jeong, Soung Won; Jang, Jae-Young; Yoo, Jeong Ju; Kim, Sang Gyune; Jin, Young-Joo; Cheon, Gab Jin; Kim, Byung Seok; Seo, Yeon Seok; Kim, Hyoungsu; Sinn, Dong Hyun; Chung, Woo Jin; Kim, Hwi Young; Lee, Han Ah; Nam, Seung Woo; Kim, In Hee; Kim, Ji Hoon; Chae, Hee Bok; Sohn, Joo Hyun; Cho, Ju Yeon; Kim, Yoon Jun; Yang, Jin Mo; Park, Jung Gil; Kim, Won; Cho, Hyun Chin; Kim, Dong Joon; KACLiF Study Grp Abstract: Background/Aims: Acute decompensation (AD) is defined as the development of complications related to portal hypertension and liver dysfunction that affect the progression of chronic liver disease (CLD) or liver cirrhosis (LC). Variations exist in patient demographics and prognostic outcomes of AD based on the aetiology of CLD, encompassing LC. However, limited research has been conducted to analyse these discrepancies across aetiologies. Methods: The prospective Korean Acute-on-Chronic Liver Failure (KACLiF) cohort consisted of 1,501 patients who were hospitalized with AD of CLD from July 2015 to August 2018. In this study, we assess the clinical attributes and prognostic implications of AD with CLD/LC stratified by the aetiology. Results: Among 1,501 patients, the mean age was 54.7 years old and 1,118 patients (74.5%) were men. The common events of AD were GI bleeding (35.3%) and jaundice (35.0%). There was a median follow-up of 8.0 months (1.0-16.0 months). The most common aetiology of CLD was alcohol (n = 1021), followed by viral hepatitis (n = 206), viral hepatitis with alcohol-related (n = 129), cryptogenic (n = 108) and autoimmune (n = 37). Viral hepatitis with alcohol-related CLD showed a poor liver function profile and a high frequency of acute-on-chronic liver failure (ACLF) [22.1% vs. 19.6% (alcohol CLD), 8.1% (viral CLD), 5.6% (autoimmune related CLD and 16.0% (cryptogenic CLD)] with worse adverse outcomes (mortality or liver transplantation) than other aetiologies. The difference in aetiology was a significant factor for 28-day adverse outcomes in multivariate analysis even in a high MELD score (>= 15), which indicated poor baseline liver function and prognosis (p < 0.001). Conclusion: The aetiology of CLD constitutes a pivotal determinant influencing both short- and long-term adverse outcomes of AD in CLD, even among individuals presenting with elevated MELD scores. Notably, patients afflicted with viral hepatitis should exercise caution even in the consumption of modest quantities of alcohol that induced the exacerbations in the adverse outcomes associated with AD. 2025-12-01T00:00:00Z https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/27921 Title: Type 2 Biomarkers as Mediators of Clinical Remission With Biologics in Severe Asthma Authors: Pham, Duong Duc; Kwon, Hyouk-Soo; Song, Woo-Jung; Cho, You Sook; Lee, Sei Won; Ban, Ga-Young; Lee, Taehoon; Park, So-Young; Nam, Young-Hee; Lee, Byung-Jae; An, Jin; Park, Chan Sun; Rhyou, Hyo-In; Kim, Joo-Hee; Park, Hye-Kyung; Kim, Sang-Ha; Yang, Min-Suk; Kim, Min-Hye; Ahn, Kyung-Min; Shim, Ji-Su; Choi, Jeong-Hee; Kim, Sujeong; Jung, Jae-Woo; Park, Han Ki; Kim, Byung Keun; Lee, Ji-Hyang; Kim, Young-Chan; Lee, Sang Min; Kang, Sung-Yoon; Kwon, Jae-Woo; Hur, Gyu Young; Moon, Ji-Yong; Sohn, Kyoung-Hee; Kim, Mi-Ae; Kim, Sae-Hoon; Yoon, Sunyoung; Jang, An-Soo; Kim, Sang Hoon; Park, So Young; Jin, Hyun Jung; Kim, So Ri; Lee, Jae-Hyun; Bhavsar, Pankaj K.; Adcock, Ian M.; Piers, Dixey; Zounemat-kermani, Nazanin; Freda, Yang; Patel, Pujan H.; Chung, Kian Fan; Kim, Tae-Bum 2025-12-01T00:00:00Z https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/28120 Title: Patient preferences toward herpes zoster vaccination among individuals aged 50 years or older in South Korea: Findings from a discrete choice experiment Authors: Shantakumar, Sumitra; Choo, Eun Ju; Parikh, Raunak; Kwon, Taeyeon; Kim, Hyungwoo; Vandervoort, Lawrence; Grillo, Vince; Lee, Jacob Abstract: In South Korea, the increasing incidence of herpes zoster (HZ) and aging population warrant consideration of HZ vaccination for older adults. There is a need to understand the HZ vaccine-related preferences of adults aged >= 50 years and adult children (working or financially independent adults contributing to healthcare decision-making for their parents aged >= 50 years). A discrete choice experiment was conducted to elicit HZ vaccine preferences of the HZ-na & iuml;ve general public aged >= 50 years (n = 500), current/former HZ patients aged >= 50 years (n = 150), and adult children (n = 150). An online questionnaire was administered through March-May 2023; for each preference-elicitation question, respondents selected between three hypothetical HZ vaccine profiles, characterized by five attributes with varying levels, or "no vaccine". Respondents generally accepted an increased number of doses (from one to two) for a longer protection duration (from >= 4 to >= 7 or >= 10 years). By mean relative importance (RI), protection duration (RI: 37.1%; 95% confidence interval [CI]: 36.0%, 38.1%), lifetime HZ risk reduction (27.3%; 95% CI: 26.3%, 28.4%) and short-term side effects (14.9%; 95% CI: 14.1%, 15.6%) had the strongest impact on respondents' HZ vaccine decision-making. Adult children viewed short-term side effects with significantly greater RI than the general public and current/former HZ patients (19.1%, 13.5%, 15.2%, respectively, p < .001). Respondents with selected comorbidities placed higher RI than those without comorbidities on protection duration (39.3% versus 34.2%, p < .001) and lower RI on prevention of HZ-related complications (8.7% versus 10.4%, p = .007). Findings may guide health policy design/refinement and physician-patient conversations on HZ vaccination/vaccines. [GRAPHICS] . 2025-12-01T00:00:00Z https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/28250 Title: Association Between MUC13 Gene Polymorphisms and Exacerbations of Asthma Under the Influence of Cigarette Smoking Authors: Bang, Ji-Hong; Son, Ji-Hye; Lee, Jong-Uk; Kim, Min Kyung; Park, Seung-lee; Seo, Eun-Jeong; Park, Jong-Sook; Chang, Hun Soo; Park, Choon-Sik Abstract: Acute exacerbation of asthma is often characterized by increased mucus production and hypersecretion. While mucins are believed to play a role in the pathogenesis and pathophysiology of airway diseases, no genetic studies on mucin genes have been conducted to date. We initially analyzed a genome-wide association dataset of 608 asthmatics, focusing on mucin gene polymorphisms. Subsequently, we conducted fine genotyping of the MUC13 gene in a separate cohort of 704 bronchial asthma patients monitored for over a year. Using generalized linear models and multiple logistic regression analyses, we evaluated the genetic associations of single nucleotide polymorphisms (SNPs) with the frequency of annual exacerbations and the likelihood of frequent exacerbations. Among 105 SNPs in 14 mucin genes analyzed, rs6765247 in MUC13 showed the most significant association with annual asthma exacerbation frequency. Fine genotyping revealed that individuals homozygous for the minor allele of rs6765247T>G had significantly more annual exacerbations compared to those with the common allele (mean +/- SD; 0.94 +/- 1.73 vs. 0.43 +/- 1.02 and 0.35 +/- 0.79, p = 0.001). The frequency of minor allele homozygotes was 3.2 times higher in frequent exacerbators than in nonfrequent exacerbators. The associations were particularly significant in smokers (interaction p = 0.009). These findings indicate that MUC13 is important in exacerbating asthma due to smoking and could be used as a marker to predict frequent exacerbations in smokers. 2025-06-01T00:00:00Z