Anti-adipogenic effect of Artemisia annua in diet-induced-obesity mice model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baek, Hye Kyung | - |
dc.contributor.author | Shim, Hyeji | - |
dc.contributor.author | Lim, Hyunmook | - |
dc.contributor.author | Shim, Minju | - |
dc.contributor.author | Kim, Chul-Kyu | - |
dc.contributor.author | Park, Sang-Kyu | - |
dc.contributor.author | Lee, Yong Seok | - |
dc.contributor.author | Song, Ki-Duk | - |
dc.contributor.author | Kim, Sung-Jo | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.date.accessioned | 2021-08-11T19:25:06Z | - |
dc.date.available | 2021-08-11T19:25:06Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1229-845X | - |
dc.identifier.issn | 1976-555X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10100 | - |
dc.description.abstract | Obesity has increased continuously in western countries during the last several decades and recently become a problem in developing countries. Currently, anti-obesity drugs originating from natural products are being investigated for their potential to overcome adverse effects associated with chemical drugs. Artemisinic acid, which was isolated from the well-known anti-malaria herb Artemisia annua (AA) L., was recently shown to possess anti-adipogenic effects in vitro. However, the anti-adipogenic effects of AA in animal models have not yet been investigated. Therefore, we conducted daily oral administration with AA water extract in a diet-induced obesity animal model and treated 3T3-L1 cells with AA to confirm the anti-adipogenic effects in the related protein expressions. We then evaluated the physiology, adipose tissue histology and mRNA expressions of many related genes. Inhibition of adipogenesis by the AA water extract was observed in vitro. In the animal model, weight gain was significantly lower in the AA treated group, but there were no changes in food intake volume or calories. Reductions in lipid droplet size and mRNA expression associated with adipogenesis were also observed in animal epididymal fat. This study is the first to report that AA has an anti-obese effects in vivo. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한수의학회 | - |
dc.title | Anti-adipogenic effect of Artemisia annua in diet-induced-obesity mice model | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4142/jvs.2015.16.4.389 | - |
dc.identifier.scopusid | 2-s2.0-84950309444 | - |
dc.identifier.wosid | 000367122000001 | - |
dc.identifier.bibliographicCitation | Journal of Veterinary Science, v.16, no.4, pp 389 - 396 | - |
dc.citation.title | Journal of Veterinary Science | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 389 | - |
dc.citation.endPage | 396 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002058368 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | adipogenesis | - |
dc.subject.keywordAuthor | animal model | - |
dc.subject.keywordAuthor | Artemisia annua | - |
dc.subject.keywordAuthor | diet induced obesity | - |
dc.subject.keywordAuthor | obesity | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.