The likelihood of having a serum PSA level of >= 2.5 ng/mL according to the degree of fatty liver disease in a screened population
- Authors
- Yoon, Jong Hyun; Yang, Hee Jo; Kim, Jae Heon; Doo, Seung Whan; Yang, Won Jae; Hwang, Jiyoung; Hong, Seong Sook; Park, Suyeon; Cho, Dae Yeon
- Issue Date
- Nov-2015
- Publisher
- Canadian Urological Association
- Keywords
- The likelihood of having a serum PSA level of ≥2.5 ng/mL accordingto the degree of fatty liver disease in a screened population
- Citation
- Journal of the Canadian Urological Association, v.9, no.11-12, pp E868 - E872
- Journal Title
- Journal of the Canadian Urological Association
- Volume
- 9
- Number
- 11-12
- Start Page
- E868
- End Page
- E872
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10156
- DOI
- 10.5489/cuaj.2395
- ISSN
- 1911-6470
1920-1214
- Abstract
- Introduction: We sought to investigate the impact of fatty liver disease (FLD) on prostate cancer (PCa) screening by estimating the odds of having a prostate-specific antigen (PSA) value over the cutoff used to prompt for the recommendation of prostate biopsy. Methods: Between 2007 and 2013, 18 533 native Korean men eligible to receive a serum PSA test, liver profiles, and abdominal ultrasonography were recruited. Logistic regression was used to estimate the odds of an abnormal PSA (>= 2.5 ng/mL) in these men (age 45-75 years, PSA <= 10 ng/mL) in relation to FLD. The FLD status was categorized as normal, mild, moderate, and severe grade by abdominal sonography. Results: A total of 16 563 men (89.4%) were included in the study after applying the inclusion criteria. Liver profiles were negatively correlated with the serum PSA level. After controlling for age and obesity, there was a statistically significant trend towards a lower likelihood of having a serum PSA level of >= 2.5 ng/mL with severe FLD, having a 34.7% lower likelihood (odds ratio 0.653, 95% confidence interval 0.477-0.88; p<0.01) compared to men in the normal group. Conclusions: Severe FLD is an independent predictor of a lower likelihood of having abnormal PSA level. Further studies are needed to better define these results in clinical biopsy practice.
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