Prenatal Particulate-Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study
DC Field | Value | Language |
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dc.contributor.author | Yang, Song-I | - |
dc.contributor.author | Kim, Byoung-Ju | - |
dc.contributor.author | Lee, So-Yeon | - |
dc.contributor.author | Kim, Hyo-Bin | - |
dc.contributor.author | Lee, Cheol Min | - |
dc.contributor.author | JinhoYu | - |
dc.contributor.author | Kang, Mi-Jin | - |
dc.contributor.author | Yu, Ho-Sung | - |
dc.contributor.author | Lee, Eun | - |
dc.contributor.author | Jung, Young-Ho | - |
dc.contributor.author | Kim, Hyung Young | - |
dc.contributor.author | Seo, Ju-Hee | - |
dc.contributor.author | Kwon, Ji-Won | - |
dc.contributor.author | Song, Dae Jin | - |
dc.contributor.author | Jang, GwangCheon | - |
dc.contributor.author | Kim, Woo-Kyung | - |
dc.contributor.author | Shim, Jung Yeon | - |
dc.contributor.author | Lee, Soo-Young | - |
dc.contributor.author | Yang, Hyeon Jong | - |
dc.contributor.author | Suh, Dong In | - |
dc.contributor.author | Hong, Seo Ah | - |
dc.contributor.author | Choi, Kil-Yong | - |
dc.contributor.author | Shin, Youn Ho | - |
dc.contributor.author | Ahn, Kangmo | - |
dc.contributor.author | Kim, Kyung Won | - |
dc.contributor.author | Kim, Eun-Jin | - |
dc.contributor.author | Hong, Soo-Jong | - |
dc.date.accessioned | 2021-08-11T19:26:19Z | - |
dc.date.available | 2021-08-11T19:26:19Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10199 | - |
dc.description.abstract | Purpose: To investigate whether prenatal exposure to indoor fine particulate matter (PM2.5) and environmental tobacco smoke (ETS) affects susceptibility to respiratory tract infections (RTIs) in infancy, to compare their effects between prenatal and postnatal exposure, and to determine whether genetic factors modify these environmental effects. Methods: The study population consisted of 307 birth cohort infants. A diagnosis of RTIs was based on parental report of a physician's diagnosis. Indoor PM2.5 and ETS levels were measured during pregnancy and infancy. TaqMan was used for genotyping of nuclear factor erythroid 2-related factor(Nn2) (rs6726395), glutathione-S-transferase-pi (GSTP) 1 (rs1695), and glutathione-S-transferase-mu (GSTM) 1. Microarrays were used for genome-wide methylation analysis. Results: Prenatal exposure to indoor PM2.5 increased the susceptibility of lower Fills (LRTIs) in infancy (adjusted odds ratio [aOR]=2.11). In terms of combined exposure to both indoor PM2.5 and ETS, prenatal exposure to both pollutants increased susceptibility to LRTIs (aOH=6.56); however, this association was not found for postnatal exposure. The Nrf2 GG (aOR=23.69), GSTM1 null (aOR=8.18), and GSTP1 AG or GO (aOR=7.37) genotypes increased the combined LRTIs-promoting effects of prenatal exposure to the 2 indoor pollutants. Such effects of prenatal indoor PM(2.)5 and ETS exposure were not found for upper RTIs. Conclusions: Prenatal exposure to both indoor PM2.5 and ETS may increase susceptibility to LRTIs. This effect can be modified by polymorphisms in reactive oxygen species-related genes. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한천식알레르기학회 | - |
dc.title | Prenatal Particulate-Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4168/aair.2015.7.6.573 | - |
dc.identifier.scopusid | 2-s2.0-84941118325 | - |
dc.identifier.wosid | 000363907100008 | - |
dc.identifier.bibliographicCitation | Allergy, Asthma & Immunology Research, v.7, no.6, pp 573 - 582 | - |
dc.citation.title | Allergy, Asthma & Immunology Research | - |
dc.citation.volume | 7 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 573 | - |
dc.citation.endPage | 582 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002042658 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | ENVIRONMENTAL TOBACCO-SMOKE | - |
dc.subject.keywordPlus | POLYCYCLIC AROMATIC-HYDROCARBONS | - |
dc.subject.keywordPlus | PROSPECTIVE BIRTH COHORT | - |
dc.subject.keywordPlus | S-TRANSFERASE M1 | - |
dc.subject.keywordPlus | AIR-POLLUTION | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | INTRAUTERINE EXPOSURE | - |
dc.subject.keywordPlus | SOURCE APPORTIONMENT | - |
dc.subject.keywordPlus | ALLERGIC DISEASES | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordAuthor | Prenatal exposure | - |
dc.subject.keywordAuthor | particulate matter | - |
dc.subject.keywordAuthor | tobacco smoke | - |
dc.subject.keywordAuthor | respiratory tract infections | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | methylation | - |
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