Vitamin D deficiency in Parkinson's disease patients with orthostatic hypotension

Abstract

ObjectivesThe purpose of our study was to investigate the associations between serum vitamin D3 levels and orthostatic hypotension (OH) in patients with Parkinson's disease (PD). Materials and methodsFifty-five patients with PD were enrolled in this study. Blood pressure (BP) measurements were gathered while the patients were in the supine position and while standing up. Then, the patients were divided into two groups: PD patients with and without OH. We compared the levels of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D-3 (calcitriol) between the two groups. ResultsSerum 25-hydroxyvitamin D and calcitriol levels were significantly decreased in patients with OH compared with those without OH. The systolic and diastolic BPs and symptom severities significantly negatively correlated with the serum 25-hydroxyvitamin D and calcitriol levels. ConclusionsAlthough the underlying mechanism for this association is not fully understood, our results suggest that low vitamin D status is associated with OH in patients with PD.