Factor analysis of the biochemical markers related to liver cirrhosis

Abstract

Objectives: The purpose of this study was to find the correlations between biochemical study and liver cirrhosis. Methods: The patients had liver biopsy to check the degree of their liver fibrosis, from August 2013 to August 2014 at the current medical center. In order to find the etiology of hepatitis, a research was done on gender, age, weight, and biochemical study through the investigation of subjects' medical record and medical history. For biochemical study, we examined hemoglobin, platelets, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, gamma-glutamyl transferase (GGT), prothrombin time (PT), and international normalised ratio (INR). We also analyzed the factors that are related to liver cirrhosis. Results: As a result, the patients at liver cirrhosis F >= 2 stage showed 0.973, which is higher than the patients at FO stage with 0.943. F >= 2 stage of hemoglobin was 0.544, which is lower than FO stage of hemoglobin with 0.817. Platelet count in F >= 2 stage was 0.417, which is higher than FO stage with 0.074. For Albumin, F >= 2 stage was 0.155 when FO stage was 0.135. ATS's F >= 2 stage was 0.665, which is 6 times higher than FO stage with 0.100. Moreover, in the case of GGT, F >= 2 stage was higher with 0.492 than FO stage with 0.078. Conclusions: In conclusion, it was confirmed that there is an increase in liver cirrhosis in the following general characteristics and biochemical factors: increase of age, increase of GGT, decrease of albumin, increase of the total bilirubin, and growth of INR (International Normalized Ratio).