Survival Advantage Associated with Metformin Usage in Hepatocellular Carcinoma Patients Receiving Radiotherapy: A Propensity Score Matching Analysis
DC Field | Value | Language |
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dc.contributor.author | Jang, Won Il | - |
dc.contributor.author | Kim, Mi-Sook | - |
dc.contributor.author | Lim, Jung Sub | - |
dc.contributor.author | Yoo, Hyung Jun | - |
dc.contributor.author | Seo, Young Seok | - |
dc.contributor.author | Han, Chul Ju | - |
dc.contributor.author | Park, Su Cheol | - |
dc.contributor.author | Kay, Chul Seung | - |
dc.contributor.author | Kim, Myungsoo | - |
dc.contributor.author | Jang, Hong Seok | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Chang, Ah Ram | - |
dc.contributor.author | Park, Hae Jin | - |
dc.date.accessioned | 2021-08-11T19:44:55Z | - |
dc.date.available | 2021-08-11T19:44:55Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.issn | 1791-7530 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10338 | - |
dc.description.abstract | Background: The present study aimed to evaluate the effects of metformin on the clinical outcomes of patients receiving radiotherapy for inoperable hepatocellular carcinoma. Patients and Methods: The medical records of 217 patients treated with stereotactic body or hypofractionated radiotherapy for inoperable hepatocellular carcinoma were reviewed. Patients were divided into the metformin group (n = 19) and the non-metformin group (n = 198), including those with diabetes (n = 29), and those without (n = 169). We performed a propensity score-matching analysis comparing the two groups. Results: In the propensity score-matched cohort (n = 76), the overall survival rate of the metformin group was higher than that of the non-metformin group (2-year, 76% vs. 37%, p = 0.022). The adjusted Cox proportional hazards model revealed that metformin usage was a significant factor for mortality (adjusted hazard ratio = 0.361; 95% confidence interval = 0.139-0.935). Conclusion: The use of metformin in patients with hepatocellular carcinoma receiving radiotherapy was associated with higher overall survival. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.title | Survival Advantage Associated with Metformin Usage in Hepatocellular Carcinoma Patients Receiving Radiotherapy: A Propensity Score Matching Analysis | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.scopusid | 2-s2.0-84939634598 | - |
dc.identifier.wosid | 000359311000064 | - |
dc.identifier.bibliographicCitation | Anticancer Research, v.35, no.9, pp 5047 - 5054 | - |
dc.citation.title | Anticancer Research | - |
dc.citation.volume | 35 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 5047 | - |
dc.citation.endPage | 5054 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | STEREOTACTIC BODY RADIOTHERAPY | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | NEGATIVE BREAST-CANCER | - |
dc.subject.keywordPlus | DIABETIC-PATIENTS | - |
dc.subject.keywordPlus | IONIZING-RADIATION | - |
dc.subject.keywordPlus | IMPROVED RESPONSE | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | metformin | - |
dc.subject.keywordAuthor | radiotherapy | - |
dc.subject.keywordAuthor | survival | - |
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