Nonhypervascular Hypointense Nodules at Gadoxetic Acid-enhanced MR Imaging in Chronic Liver Disease: Diffusion-weighted Imaging for Characterization
DC Field | Value | Language |
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dc.contributor.author | Hwang, Jiyoung | - |
dc.contributor.author | Kim, Young Kon | - |
dc.contributor.author | Jeong, Woo Kyoung | - |
dc.contributor.author | Choi, Dongil | - |
dc.contributor.author | Rhim, Hyunchul | - |
dc.contributor.author | Lee, Won Jae | - |
dc.date.accessioned | 2021-08-11T19:46:38Z | - |
dc.date.available | 2021-08-11T19:46:38Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.issn | 1527-1315 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10503 | - |
dc.description.abstract | Purpose: To compare the diagnostic performance of magnetic resonance (MR) imaging features, including those on diffusion-weighted (DW) and T2-weighted images, in differentiating between hypovascular hepatocellular carcinoma (HCC) and dysplastic nodules seen as hypointense nodules at hepatobiliary phase gadoxetic acid-enhanced MR imaging. Materials and Methods: The institutional review board approved this retrospective study and waived the need to obtain informed patient consent. There were 53 patients (39 men and 14 women; age range, 32-75 years) with histologically proven hypovascular HCCs (n = 25) and/or dysplastic nodules (n = 31) who underwent gadoxetic acid-enhanced MR imaging at 3.0-T between March 2011 and January 2014. Images of 25 HCCs and 31 dysplastic nodules were analyzed for nodule size; signal intensity on T1- and T2-weighted, portal venous phase, and DW (b value = 800 sec/mm(2)) images; and intralesional fat. Correlations between the hyperintensity grade of lesions and the liver-to-lesion signal intensity ratio at T2-weighted and DW imaging were determined by means of analysis with generalized estimating equations. Results: Hyperintensity at T2-weighted and DW imaging and hypointensity in the portal venous phase were significant features for differentiating hypovascular HCCs from dysplastic nodules (P < .05). The sensitivity of DW imaging tended to be higher than that of T2-weighted imaging (72.0% [18 of 25] vs 40.0% [10 of 25]; P = .008 for grade 2 and 3 hyperintensity). Use of the parameter of hyperintensity similar to or slightly lower than the signal intensity of the spleen on DW images (b value = 800 sec/mm(2)) yielded a specificity of 100% (31 of 31) for the diagnosis of hypovascular HCC by differentiating it from a dysplastic nodule. Conclusion: Hyperintensity at DW imaging could be a useful MR imaging feature for differentiating hypovascular HCCs from dysplastic nodules seen as hypointense nodules at gadoxetic acid-enhanced MR imaging. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Radiological Society of North America | - |
dc.title | Nonhypervascular Hypointense Nodules at Gadoxetic Acid-enhanced MR Imaging in Chronic Liver Disease: Diffusion-weighted Imaging for Characterization | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1148/radiol.15141350 | - |
dc.identifier.scopusid | 2-s2.0-84937038023 | - |
dc.identifier.wosid | 000359708400015 | - |
dc.identifier.bibliographicCitation | Radiology, v.276, no.1, pp 137 - 146 | - |
dc.citation.title | Radiology | - |
dc.citation.volume | 276 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 137 | - |
dc.citation.endPage | 146 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | SMALL HEPATOCELLULAR CARCINOMAS | - |
dc.subject.keywordPlus | HEPATOBILIARY-PHASE | - |
dc.subject.keywordPlus | CIRRHOTIC LIVER | - |
dc.subject.keywordPlus | DYSPLASTIC NODULES | - |
dc.subject.keywordPlus | HYPOVASCULAR NODULES | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | NATURAL COURSE | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | IMAGES | - |
dc.subject.keywordAuthor | Nonhypervascular HypointenseNodules at Gadoxetic Acid–enhanced MR Imagingin Chronic Liver Disease | - |
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