CD8 alpha(-) Dendritic Cells Induce Antigen-Specific T Follicular Helper Cells Generating Efficient Humoral Immune Responses
DC Field | Value | Language |
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dc.contributor.author | Shin, Changsik | - |
dc.contributor.author | Han, Jae-A | - |
dc.contributor.author | Koh, Hyein | - |
dc.contributor.author | Choi, Bongseo | - |
dc.contributor.author | Cho, Yongbin | - |
dc.contributor.author | Jeong, Hyeongmin | - |
dc.contributor.author | Ra, Jea-Sun | - |
dc.contributor.author | Sung, Pil Soo | - |
dc.contributor.author | Shin, Eui-Cheol | - |
dc.contributor.author | Ryu, Seongho | - |
dc.contributor.author | Do, Yoonkyung | - |
dc.date.accessioned | 2021-08-11T20:24:01Z | - |
dc.date.available | 2021-08-11T20:24:01Z | - |
dc.date.issued | 2015-06-30 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10542 | - |
dc.description.abstract | Recent studies on T follicular helper (Tfh) cells have significantly advanced our understanding of T cell-dependent B cell responses. However, little is known about the early stage of Tfh cell commitment by dendritic cells (DCs), particularly by the conventional CD8 alpha(+) and CD8 alpha(-) DC subsets. We show that CD8 alpha(-) DCs localized at the interfollicular zone play a pivotal role in the induction of antigen-specific Tfh cells by upregulating the expression of Icosl and Ox40l through the non-canonical NF-kappa B signaling pathway. Tfh cells induced by CD8 alpha(-) DCs function as true B cell helpers, resulting in significantly increased humoral immune responses against various human pathogenic antigens, including Yersinia pestis LcrV, HIV Gag, and hepatitis B surface antigen. Our findings uncover a mechanistic role of CD8 alpha(-) DCs in the initiation of Tfh cell differentiation and thereby provide a rationale for investigating CD8 alpha(-) DCs in enhancing antigen-specific humoral immune responses for improving vaccines and therapeutics. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Cell Press | - |
dc.title | CD8 alpha(-) Dendritic Cells Induce Antigen-Specific T Follicular Helper Cells Generating Efficient Humoral Immune Responses | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.celrep.2015.05.042 | - |
dc.identifier.scopusid | 2-s2.0-84933678575 | - |
dc.identifier.wosid | 000357393500009 | - |
dc.identifier.bibliographicCitation | Cell Reports, v.11, no.12, pp 1929 - 1940 | - |
dc.citation.title | Cell Reports | - |
dc.citation.volume | 11 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1929 | - |
dc.citation.endPage | 1940 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | CXC CHEMOKINE RECEPTOR-5 | - |
dc.subject.keywordPlus | HEPATITIS-B-VACCINE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ANTIBODY-PRODUCTION | - |
dc.subject.keywordPlus | HIV-INFECTION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | ICOS | - |
dc.subject.keywordPlus | FOLLICLES | - |
dc.subject.keywordAuthor | Dendritic cell | - |
dc.subject.keywordAuthor | immunology | - |
dc.subject.keywordAuthor | follicular helper T cell | - |
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