Detailed Information

Cited 0 time in webofscience Cited 1 time in scopus
Metadata Downloads

Functional analysis of sepiapterin reductase in Drosophila melanogaster

Full metadata record
DC Field Value Language
dc.contributor.authorKim, Kiyoung-
dc.contributor.authorKim, Heuijong-
dc.contributor.authorYim, Jeongbin-
dc.date.accessioned2021-08-11T20:24:33Z-
dc.date.available2021-08-11T20:24:33Z-
dc.date.issued2015-06-
dc.identifier.issn0933-4807-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10612-
dc.description.abstractSepiapterin reductase (SR) is a key enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin. BH4 deficiencies have been implicated in several neurological disorders. Here, we characterized sepiapterin reductase (SR) loss-of-function mutants in Drosophila melanogaster and demonstrated that SR mutations are responsible for hyposensitivity to oxidative stress. Biochemical analysis further revealed that SR activity and BH4 levels in SR mutants were significantly reduced. Furthermore, we showed that the levels of phosphorylated Akt and total Akt protein were increased in SR mutants. Our findings indicate that SR plays an important role in the Akt pathway and that SR mutants will be a valuable tool for investigating the physiological functions of BH4.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherInternational Society of Pteridinology-
dc.titleFunctional analysis of sepiapterin reductase in Drosophila melanogaster-
dc.typeArticle-
dc.publisher.location독일-
dc.identifier.doi10.1515/pterid-2014-0018-
dc.identifier.scopusid2-s2.0-84930436419-
dc.identifier.wosid000355270500003-
dc.identifier.bibliographicCitationPteridines, v.26, no.2, pp 63 - 68-
dc.citation.titlePteridines-
dc.citation.volume26-
dc.citation.number2-
dc.citation.startPage63-
dc.citation.endPage68-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.subject.keywordPlusTETRAHYDROBIOPTERIN BIOSYNTHESIS-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlusLOCUS-
dc.subject.keywordPlusDEFICIENCY-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusENZYMES-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusONSET-
dc.subject.keywordPlusAGE-
dc.subject.keywordAuthorAkt-
dc.subject.keywordAuthorBH4-
dc.subject.keywordAuthorDrosophila-
dc.subject.keywordAuthorsepiapterin reductase-
dc.subject.keywordAuthortetrahydrobiopterin-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Ki young photo

Kim, Ki young
Graduate School (Department of Medical Bioscience)
Read more

Altmetrics

Total Views & Downloads

BROWSE