Relations Between Pathological Markers and Radioiodine Scan and F-18-FDG PET/CT Findings in Papillary Thyroid Cancer Patients With Recurrent Cervical Nodal Metastases
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeong Won | - |
dc.contributor.author | Min, Hye Sook | - |
dc.contributor.author | Lee, Sang Mi | - |
dc.contributor.author | Kwon, Hyun Woo | - |
dc.contributor.author | Chung, June-Key | - |
dc.date.accessioned | 2021-08-11T20:24:35Z | - |
dc.date.available | 2021-08-11T20:24:35Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.issn | 1869-3482 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10615 | - |
dc.description.abstract | Purpose The aim of this study was to investigate relationships between the immunohistochemical results and radioiodine scan and F-18-FDG PET findings in papillary thyroid cancer (PTC) patients with recurrent cervical nodal metastases. Methods A total of 46 PTC patients who had undergone a radioiodine scan and/or F-18-FDG PET/CT and a subsequent operation on recurrent cervical lymph nodes were enrolled. Twenty-seven patients underwent F-18-FDG PET/CT, 8 underwent radioiodine scans, and 11 underwent both scans. In all surgical specimens, the immunoexpressions of thyroglobulin (Tg), sodium-iodide symporter (NIS), glucose transporter 1 (Glut-1), and somatostatin receptor 1 and 2A (SSTR1 and SSTR2A) were assessed, and associations between these expressions and radioiodine scan and F-18-FDG PET findings were evaluated. Results Of the 38 patients who underwent F-18-FDG PET/CT, all patients with weak Tg expression had positive F-18-FDG uptake, while only 45 % of the patients with moderate or strong Tg expression showed positive uptake (p= 0.01). The proportion of patients with positive F-18-FDG uptake increased as the degree of Glut-1 expression with luminal accentuation increased. Of the 19 patients who underwent a radioiodine scan, the proportion with positive radioiodine uptake was greater among patients with strong NIS and SSTR2A expression than among patients expressing these markers at weak levels (p= 0.04 for all). All three patients with weak Tg expression were negative for radioiodine uptake. Conclusion The F-18-FDG uptakes of recurrent cervical nodes are related to strong Glut-1 expression with luminal accentuation and weak Tg expression, whereas radioiodine uptake is related to the strong expressions of NIS and SSTR2A. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한핵의학회 | - |
dc.title | Relations Between Pathological Markers and Radioiodine Scan and F-18-FDG PET/CT Findings in Papillary Thyroid Cancer Patients With Recurrent Cervical Nodal Metastases | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s13139-015-0324-6 | - |
dc.identifier.scopusid | 2-s2.0-84931262772 | - |
dc.identifier.wosid | 000217908200006 | - |
dc.identifier.bibliographicCitation | Nuclear Medicine and Molecular Imaging, v.49, no.2, pp 127 - 134 | - |
dc.citation.title | Nuclear Medicine and Molecular Imaging | - |
dc.citation.volume | 49 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 134 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001998166 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordAuthor | Thyroid cancer | - |
dc.subject.keywordAuthor | F-18-fluorodeoxyglucose | - |
dc.subject.keywordAuthor | Positron emission tomography | - |
dc.subject.keywordAuthor | Radioiodine | - |
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