The effect of combination treatment using palonosetron and dexamethasone for the prevention of postoperative nausea and vomiting versus dexamethasone alone in women receiving intravenous patient-controlled analgesia
DC Field | Value | Language |
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dc.contributor.author | Ryoo, Seung-hwa | - |
dc.contributor.author | Yoo, Jae Hwa | - |
dc.contributor.author | Kim, Mun Gyu | - |
dc.contributor.author | Lee, Ki Hoon | - |
dc.contributor.author | Kim, Soon Im | - |
dc.date.accessioned | 2021-08-11T20:24:37Z | - |
dc.date.available | 2021-08-11T20:24:37Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.issn | 2005-7563 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10619 | - |
dc.description.abstract | Background: The purpose of this study was to evaluate the effect of palonosetron combined with dexamethasone for the prevention of PONV compared to dexamethasone alone in women who received intravenous patient-controlled analgesia (IV-PCA) using fentanyl. Methods: In this randomized, double-blinded, placebo-controlled study, 204 healthy female patients who were scheduled to undergo elective surgery under general anesthesia followed by IV-PCA for postoperative pain control were enrolled. Patients were divided into two groups: the PD group (palonosetron 0.075 mg and dexamethasone 5 mg IV; n = 102) and the D group (dexamethasone 5 mg IV; n = 102). The treatments were given after the induction of anesthesia. The incidence of nausea, vomiting, severity of nausea, and the use of rescue anti-emetics during the first 48 hours after surgery were evaluated. Results: The incidence of PONV was significantly lower in the PD group compared with the D group during the 0-24 hours (43 vs. 59%) and 0-48 hours after surgery (45 vs. 63%) (P < 0.05). The severity of nausea during the 6- 24 hours after surgery was significantly less in the PD group compared with the D group (P < 0.05). The incidence of rescue antiemetic used was significantly lower in the PD group than in the D group during the 0-6 hours after surgery (13.1 vs. 24.5%) (P < 0.05). Conclusions: Palonosetron combined with dexamethasone was more effective in preventing PONV compared to dexamethasone alone in women receiving IV-PCA using fentanyl. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한마취통증의학회 | - |
dc.title | The effect of combination treatment using palonosetron and dexamethasone for the prevention of postoperative nausea and vomiting versus dexamethasone alone in women receiving intravenous patient-controlled analgesia | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4097/kjae.2015.68.3.267 | - |
dc.identifier.scopusid | 2-s2.0-84930463603 | - |
dc.identifier.wosid | 000420619100010 | - |
dc.identifier.bibliographicCitation | Korean Journal of Anesthesiology, v.68, no.3, pp 267 - 273 | - |
dc.citation.title | Korean Journal of Anesthesiology | - |
dc.citation.volume | 68 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 267 | - |
dc.citation.endPage | 273 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001993688 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.subject.keywordAuthor | Dexamethasone | - |
dc.subject.keywordAuthor | Palonosetron | - |
dc.subject.keywordAuthor | Postoperative nausea and vomiting | - |
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