Use of F-18-FDG PET to predict tumor progression and survival in patients with intermediate hepatocellular carcinoma treated by transarterial chemoembolization
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Jin | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Cho, Youn Hee | - |
dc.contributor.author | Jang, Hee Yoon | - |
dc.contributor.author | Song, Jeong-Yeop | - |
dc.contributor.author | Lee, Sae Hwan | - |
dc.contributor.author | Jeong, Soung Won | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Kim, Hong Su | - |
dc.contributor.author | Kim, Boo Sung | - |
dc.contributor.author | Lee, Won Hyung | - |
dc.contributor.author | Park, Jung Mi | - |
dc.contributor.author | Lee, Jae Myung | - |
dc.contributor.author | Lee, Min Hee | - |
dc.contributor.author | Choi, Deuk Lin | - |
dc.date.accessioned | 2021-08-11T20:25:20Z | - |
dc.date.available | 2021-08-11T20:25:20Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10690 | - |
dc.description.abstract | Background/Aims: F-18-Fluorodeoxyglucose positron-emission tomography (F-18-FDG PET) has been used to assess the biological behavior of hepatocellular carcinoma (HCC). In this study, we investigated the usefulness of 18F-FDG PET for predicting tumor progression and survival in patients with intermediate Barcelona Clinic Liver Cancer (BCLC) intermediate-stage HCC treated by transarterial chemoembolization (TACE). Methods: From February 2006 to March 2013, 210 patients treated with TACE, including 77 patients with BCLC intermediate-stage HCC, underwent examination by F-18-FDG PET. 18F-FDG uptake was calculated based on the tumor maximum (Tmax) standardized uptake value (SUV), the liver mean (Lmean) SUV, and the ratio of the Tmax SUV to the Lmean SUV (Tmax/Lmean). Results: The mean follow-up period for the 77 patients (52 males, 25 females; average age, 63.3 years) was 22.2 months. The median time to progression of HCC in patients with a low Tmax/Lmean 1.83) and high Tmax/Lmean 1.83) was 17 and 6 months, respectively (p < 0.001). The median overall survival time of patients with a low and high Tmax/Lmean was 44 and 14 months, respectively (p = 0.003). Multivariate analysis revealed that the Tmax/Lmean was an independent predictor of overall survival (hazard ratio [HR], 1.96; 95% confidence interval [CI], 1.210 to 3.156; p = 0.006) and tumor progression (HR, 2.05; 95% CI, 1.264 to 3.308; p = 0.004). Conclusions: 18F-FDG uptake calculated by the Tmax/Lmean using PET predicted tumor progression and survival in patients with BCLC intermediate-stage HCC treated by TACE. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내과학회 | - |
dc.title | Use of F-18-FDG PET to predict tumor progression and survival in patients with intermediate hepatocellular carcinoma treated by transarterial chemoembolization | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3904/kjim.2015.30.3.308 | - |
dc.identifier.scopusid | 2-s2.0-84929393801 | - |
dc.identifier.wosid | 000353933700005 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Internal Medicine, v.30, no.3, pp 308 - 315 | - |
dc.citation.title | The Korean Journal of Internal Medicine | - |
dc.citation.volume | 30 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 308 | - |
dc.citation.endPage | 315 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001990437 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | F-18-FLUORODEOXYGLUCOSE UPTAKE | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | CANDIDATES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | LEVEL | - |
dc.subject.keywordAuthor | Carcinoma | - |
dc.subject.keywordAuthor | hepatocellular | - |
dc.subject.keywordAuthor | Fluorodeoxyglucose F18 | - |
dc.subject.keywordAuthor | Positron-emission tomography | - |
dc.subject.keywordAuthor | Tomography | - |
dc.subject.keywordAuthor | X-ray computed | - |
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