Incidences and Prognostic Impact of c-KIT, WT1, CEBPA, and CBL Mutations, and Mutations Associated With Epigenetic Modification in Core Binding Factor Acute Myeloid Leukemia: A Multicenter Study in a Korean Population
DC Field | Value | Language |
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dc.contributor.author | Park, Sang Hyuk | - |
dc.contributor.author | Lee, Hyun Ji | - |
dc.contributor.author | Kim, In-Suk | - |
dc.contributor.author | Kang, Jeong-Eun | - |
dc.contributor.author | Lee, Eun Yup | - |
dc.contributor.author | Kim, Hyeoung-Joon | - |
dc.contributor.author | Kim, Yeo-Kyeoung | - |
dc.contributor.author | Won, Jong-Ho | - |
dc.contributor.author | Bang, Soo Mee | - |
dc.contributor.author | Kim, Hawk | - |
dc.contributor.author | Song, Moo-Kon | - |
dc.contributor.author | Chung, Joo Seop | - |
dc.contributor.author | Shin, Ho-Jin | - |
dc.date.accessioned | 2021-08-11T20:25:42Z | - |
dc.date.available | 2021-08-11T20:25:42Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.issn | 2234-3814 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10716 | - |
dc.description.abstract | Background: To identify potential molecular prognostic markers in core binding factor (CBF) AML, we analyzed incidences and prognostic impacts of mutations in c-KIT, WT1, CEBPA, CBL, and a number of epigenetic genes in CBF AML. Methods: Seventy one and 21 AML patients with t(8;21) and inv(16) were enrolled in this study, respectively. NPM1, CEBPA, c-KIT, IDH1/2, DNMT3A, EZH2, WT1, and CBL mutations were analyzed by direct sequencing. Patients were categorized with respect to c-KIT and WT1 mutation status, and both clinical features and prognoses were compared. Results: The incidences of FLT3 internal tandem duplication (ITD), NPM1, CEBPA, IDH1/2, DNMT3A, EZH2, and CBL mutations were low (<= 5%) in CBF AML patients. However, c-KIT and WT1 mutations occurred frequently (10.9% and 13.8%, respectively). t(8;21) patients with c-KIT mutations showed significantly shorter overall survival (OS) and disease free survival (DFS) periods than those without mutations (P<0.001, for both); however, although the limited number of t(8;21) patients were analyzed, WT1 mutation status did not affect prognosis significantly. Relapse or death during follow-up occurred more frequently in t(8;21) patients carrying c-KIT mutations than in those without the mutation, although the difference was significant only in a specific patient subgroup with no WT1 mutations (P=0.014). Conclusions: The incidences of mutations in epigenetic genes are very low in CBF AML; however, c-KIT and WT1 mutations occur more frequently than others. The poor prognostic impact of c-KIT mutation in t(8;21) AML patients only applies in a specific patient subgroup without WT1 mutations. The prognostic impact of WT1 mutation in CBF AML is not evident and further investigation is required. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한진단검사의학회 | - |
dc.title | Incidences and Prognostic Impact of c-KIT, WT1, CEBPA, and CBL Mutations, and Mutations Associated With Epigenetic Modification in Core Binding Factor Acute Myeloid Leukemia: A Multicenter Study in a Korean Population | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3343/alm.2015.35.3.288 | - |
dc.identifier.scopusid | 2-s2.0-84929627266 | - |
dc.identifier.wosid | 000352754600002 | - |
dc.identifier.bibliographicCitation | Annals of Laboratory Medicine, v.35, no.3, pp 288 - 297 | - |
dc.citation.title | Annals of Laboratory Medicine | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 288 | - |
dc.citation.endPage | 297 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001982055 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | RAS GENE-MUTATIONS | - |
dc.subject.keywordPlus | DNMT3A MUTATIONS | - |
dc.subject.keywordPlus | NORMAL KARYOTYPE | - |
dc.subject.keywordPlus | NUCLEOPHOSMIN 1 | - |
dc.subject.keywordPlus | FLT3 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | NPM1 | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordAuthor | Acute myeloid leukemia | - |
dc.subject.keywordAuthor | Core binding factor | - |
dc.subject.keywordAuthor | c-KIT | - |
dc.subject.keywordAuthor | Epigenetic modification | - |
dc.subject.keywordAuthor | Incidence | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | WT1 | - |
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