Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP
DC Field | Value | Language |
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dc.contributor.author | Li, Chengping | - |
dc.contributor.author | Jung, Samil | - |
dc.contributor.author | Lee, Soonduck | - |
dc.contributor.author | Jeong, Dongjun | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Kim, Keun-Il | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.contributor.author | Cheon, Chung-Il | - |
dc.contributor.author | Kim, Changjin | - |
dc.contributor.author | Kang, Young-Sook | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.accessioned | 2021-08-11T20:25:51Z | - |
dc.date.available | 2021-08-11T20:25:51Z | - |
dc.date.issued | 2015-04-10 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10724 | - |
dc.description.abstract | TRIP-Br3 and TRIP-Br1 have shown to have important biological functions. However, the function of TRIP-Br3 in tumorigenesis is not well characterized compared to oncogenic TRIP-Br1. Here, we investigated the function of TRIP-Br3 in tumorigenesis by comparing with that of TRIP-Br1. Under nutrient/serum starvation, TRIP-Br3 expression was down-regulated slightly in cancer cells and significantly in normal cells. Unexpectedly, TRIP-Br1 expression was greatly up-regulated in cancer cells but not in normal cells. Moreover, TRIP-Br3 activated autophagy while TRIP-Br1 inactivated it under serum starvation. In spite of different expression and roles of TRIP-Br3 and TRIP-Br1, both of them alleviate cell death by directly binding to and stabilizing XIAP, a potent apoptosis inhibitor, through blocking its ubiquitination. Taken together, we propose that TRIP-Br3 primarily activates the autophagy and suppresses apoptosis in nutrient sufficient condition. However, the prolonged extreme stressful condition of nutrient starvation causes a dramatic decrease of TRIP-Br3, which in turn induces apoptosis by destabilizing XIAP. Up-regulated TRIP-Br1 in cancer cells compensates this effect and delays apoptosis. This can be explained by the competitive alternative binding of TRIP-Br3 and TRIP-Br1 to the BIR2 domain of XIAP. In an extended study, our immunohistochemical analysis revealed a markedly lower level of TRIP-Br3 protein in human carcinoma tissues compared to normal epithelial tissues, implying the role of TRIP-Br3 as a tumor suppressor rather than onco-protein. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Impact Journals | - |
dc.title | Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.18632/oncotarget.3112 | - |
dc.identifier.scopusid | 2-s2.0-84928387907 | - |
dc.identifier.wosid | 000354885300013 | - |
dc.identifier.bibliographicCitation | Oncotarget, v.6, no.10, pp 7522 - 7535 | - |
dc.citation.title | Oncotarget | - |
dc.citation.volume | 6 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 7522 | - |
dc.citation.endPage | 7535 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | X-LINKED INHIBITOR | - |
dc.subject.keywordPlus | CELL-CYCLE PROGRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVATION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | SERUM STARVATION | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | BR FAMILY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | P34(SEI-1) | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Nutrient/serum starvation | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | TRIP-Br3 | - |
dc.subject.keywordAuthor | TRIP-Br1 | - |
dc.subject.keywordAuthor | XIAP | - |
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