Clinical Significance of a Negative Loop Electrosurgical Excision Procedure Biopsy in Patients With Biopsy-Confirmed High-Grade Cervical Intraepithelial Neoplasia
DC Field | Value | Language |
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dc.contributor.author | Nam, Kyehyun | - |
dc.contributor.author | Ryu, Aeli | - |
dc.contributor.author | Jeon, Seob | - |
dc.contributor.author | Kim, Jeongsig | - |
dc.contributor.author | Kwak, Jeongja | - |
dc.contributor.author | Park, Bora | - |
dc.date.accessioned | 2021-08-11T20:26:13Z | - |
dc.date.available | 2021-08-11T20:26:13Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1089-2591 | - |
dc.identifier.issn | 1526-0976 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10763 | - |
dc.description.abstract | Objective: We sought to determine which clinical factors can predict this phenomenon and to better understand the clinical significance of negative loop electrosurgical excision procedure (LEEP) findings through long-term follow-up. Methods: We identified 559 patients with biopsy-confirmed cervical intraepithelial neoplasia grade 2 or 3 (CIN 2, 3) who were treated by LEEP between February 2001 and December 2010. Preconization clinical characteristics, as well as high-risk human papillomavirus (hrHPV) status, were analyzed as possible predictors of an absence of a lesion in the specimen. The clinical significance of an absence of a lesion in the specimen, as well as other factors, was evaluated by Cox hazard regression analysis in terms of recurrence. Results: No lesion on the LEEP specimen was found in 102 (18.2%) of 559 patients with CIN 2,3 on punch biopsy. Punch biopsy status of CIN 2, low HPV viral load (<100 relative light units [RLU]), and negative or positive HPV infection other than type 16 were significantly related to no lesion in the LEEP specimen. Postoperative HPV persistence (>= 10 RLU) and same-type HPV detection were significantly related to recurrent disease of CIN 2+ (p < .001). The recurrence of patients with no lesion in LEEP did not statistically differ from that of patients with a lesion in the LEEP specimen (p = .390). Conclusions: The absence of a lesion in the LEEP specimen is very common. A negative LEEP is associated with a persistence/recurrence rate similar to that of positive LEEP. We recommend that the follow-up for patients with no lesion in the LEEP specimen should be the same as that for patients with a lesion. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Clinical Significance of a Negative Loop Electrosurgical Excision Procedure Biopsy in Patients With Biopsy-Confirmed High-Grade Cervical Intraepithelial Neoplasia | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.wosid | 000351883900023 | - |
dc.identifier.bibliographicCitation | Journal of Lower Genital Tract Disease, v.19, no.2, pp 103 - 109 | - |
dc.citation.title | Journal of Lower Genital Tract Disease | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 109 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | PREDICTS RESIDUAL/RECURRENT DISEASE | - |
dc.subject.keywordPlus | TRANSFORMATION ZONE | - |
dc.subject.keywordPlus | CONE BIOPSIES | - |
dc.subject.keywordPlus | CONIZATION | - |
dc.subject.keywordPlus | ABSENCE | - |
dc.subject.keywordAuthor | cervical intraepithelial neoplasia | - |
dc.subject.keywordAuthor | follow-up studies | - |
dc.subject.keywordAuthor | papillomavirus infections | - |
dc.subject.keywordAuthor | recurrence | - |
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