Association of restrictive ventilatory dysfunction with the development of prediabetes and type 2 diabetes in Koreans
DC Field | Value | Language |
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dc.contributor.author | Kim, Chul-Hee | - |
dc.contributor.author | Kim, Hong-Kyu | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Bae, Sung-Jin | - |
dc.contributor.author | Jung, Young-Ju | - |
dc.contributor.author | Choi, Jaewon | - |
dc.contributor.author | Park, Joong-Yeol | - |
dc.date.accessioned | 2021-08-11T20:26:16Z | - |
dc.date.available | 2021-08-11T20:26:16Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 0940-5429 | - |
dc.identifier.issn | 1432-5233 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10766 | - |
dc.description.abstract | This study was performed to investigate whether ventilatory dysfunction is a predictor for the development of prediabetes and type 2 diabetes in Koreans. We analyzed the clinical and laboratory data of 16,195 Korean adults (age 20-79 years) who underwent routine medical checkups with a mean 4.7-years (range 3.0-5.9 years) interval. Spirometry results were categorized into three patterns: normal, obstructive ventilatory dysfunction [OVD; forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < 0.70], and restrictive ventilatory dysfunction (RVD; FVC < 80 % predicted, FEV1/FVC a parts per thousand yen 0.70). Compared with subjects with normal ventilatory function, subjects with RVD had a higher incidence of type 2 diabetes (3.7 vs. 6.3 %; P < 0.001), whereas subjects with OVD did not (3.7 vs. 4.8 %; P = 0.119). On multivariate logistic regression analysis, the odds ratio (OR) of RVD for type 2 diabetes was significantly increased after adjusting for age, sex, and lifestyle factors (1.40; 95 % CI 1.10-1.78). However, further adjustment for body mass index (BMI), waist circumference, and baseline glucose level attenuated the OR to become insignificant (1.12; 95 % CI 0.86-1.47). Among the 9,461 participants who had normal fasting glucose and HbA1c levels at baseline, the OR for progression to prediabetes or diabetes in the RVD group was significantly increased (1.30; 95 % CI 1.12-1.51). The increased OR remained significant after adjusting for BMI, waist circumference, and baseline glucose level (1.26; 95 % CI 1.07-1.47). Our results indicate that restrictive, but not obstructive ventilatory dysfunction, is independently associated with development of prediabetes and precedes the development of type 2 diabetes. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Verlag | - |
dc.title | Association of restrictive ventilatory dysfunction with the development of prediabetes and type 2 diabetes in Koreans | - |
dc.type | Article | - |
dc.publisher.location | 이탈리아 | - |
dc.identifier.doi | 10.1007/s00592-014-0649-0 | - |
dc.identifier.scopusid | 2-s2.0-84939992746 | - |
dc.identifier.wosid | 000351835500016 | - |
dc.identifier.bibliographicCitation | Acta Diabetologica, v.52, no.2, pp 357 - 363 | - |
dc.citation.title | Acta Diabetologica | - |
dc.citation.volume | 52 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 357 | - |
dc.citation.endPage | 363 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject.keywordPlus | REDUCED LUNG-FUNCTION | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | NATIONAL-HEALTH | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS RISK | - |
dc.subject.keywordPlus | CARDIOVASCULAR RISK | - |
dc.subject.keywordPlus | VITAL CAPACITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordAuthor | Pulmonary function | - |
dc.subject.keywordAuthor | Restrictive ventilatory dysfunction | - |
dc.subject.keywordAuthor | Prediabetes | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
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