Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey
DC Field | Value | Language |
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dc.contributor.author | Myung, Jun-Ho | - |
dc.contributor.author | Seo, Hyun-Jeong | - |
dc.contributor.author | Park, Soo-Jeong | - |
dc.contributor.author | Kim, Bo-Young | - |
dc.contributor.author | Shin, Il-Sang | - |
dc.contributor.author | Jang, Jun-Hak | - |
dc.contributor.author | Kim, Yun-Kyung | - |
dc.contributor.author | Jang, An-Soo | - |
dc.date.accessioned | 2021-08-11T20:43:59Z | - |
dc.date.available | 2021-08-11T20:43:59Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10833 | - |
dc.description.abstract | Background/Aims: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness. Methods: We counted eosinophils on nasal smears, and performed spirometry, allergic skin tests, and methacholine challenge tests in 308 schoolchildren plus a questionnaire on respiratory symptoms. The methacholine concentration causing a 20% fall in forced expiratory volume in 1 second (PC20 < 25 mg/mL) was used as the threshold of bronchial hyperresponsiveness (BHR). Results: In total, 26% of subjects had positive nasal eosinophils on a smear, and 46.2% of subjects had BHR at < 25 mg/mL methacholine PC20. Nasal symptoms were higher in subjects with than without nasal eosinophils (p = 0.012). Asthma symptoms did not differ between subjects with and without nasal eosinophils. Nasal eosinophils were higher in subjects with atopy than those without (p = 0.006), and there was no difference in PC20 methacholine according to atopy (15.5 +/- 1.07 vs. 17.5 +/- 0.62; p > 0.05). No difference in BHR was detected when comparing subjects with and without nasal eosinophils. There were significant differences in the PC20 between subjects with greater than 50% nasal eosinophils and without nasal eosinophils (11.01 +/- 2.92 mg/mL vs. 17.38 +/- 0.61 mg/m.L; p < 0.004 Conclusions: These findings demonstrated that nasal eosinophilic inflammation might contribute to lower airway responsiveness in schoolchildren, based on an epidemiological survey. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내과학회 | - |
dc.title | Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3904/kjim.2015.30.2.226 | - |
dc.identifier.scopusid | 2-s2.0-84924408528 | - |
dc.identifier.wosid | 000351419700014 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Internal Medicine, v.30, no.2, pp 226 - 231 | - |
dc.citation.title | The Korean Journal of Internal Medicine | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 226 | - |
dc.citation.endPage | 231 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001970687 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ALLERGIC RHINITIS | - |
dc.subject.keywordPlus | BRONCHIAL HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | FLOW | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Eosinophils | - |
dc.subject.keywordAuthor | Nose | - |
dc.subject.keywordAuthor | Bronchial hyperreactivity | - |
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