Neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Gun | - |
dc.contributor.author | Yoo, Dae Young | - |
dc.contributor.author | Jung, Hyo Young | - |
dc.contributor.author | Nam, Sung Min | - |
dc.contributor.author | Kim, Jong Whi | - |
dc.contributor.author | Choi, Jung Hoon | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.contributor.author | Yoon, Yeo Sung | - |
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Moon, Seung Myung | - |
dc.date.accessioned | 2021-08-11T20:44:12Z | - |
dc.date.available | 2021-08-11T20:44:12Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1673-5374 | - |
dc.identifier.issn | 1876-7958 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10849 | - |
dc.description.abstract | In this study, we investigated the effects of streptozotocin-induced type 1 diabetes on antioxidant-like protein-1 immunoreactivity, protein carbonyl levels, and malondialdehyde formation, a marker for lipid peroxidation, in the hippocampus. For this study, streptozotocin (75 mg/kg) was intraperitoneally injected into adult rats to induce type 1 diabetes. The three experimental parameters were determined at 2, 3, 4 weeks after streptozotocin treatment. Fasting blood glucose levels significantly increased by 20.7-21.9 mM after streptozotocin treatment. The number of antioxidant-like protein-1 immunoreactive neurons significantly decreased in the hippocampal CA1 region, but not the dentate gyrus, 3 weeks after streptozotocin treatment compared to the control group. Malondialdehyde and protein carbonyl levels, which are modified by oxidative stress, significantly increased with a peak at 3 weeks after malondialdehyde treatment, and then decreased 4 weeks after malondialdehyde treatment. These results suggest that neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress 3 weeks after malondialdehyde treatment. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Neural Regeneration Research | - |
dc.title | Neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes | - |
dc.type | Article | - |
dc.publisher.location | 인도 | - |
dc.identifier.doi | 10.4103/1673-5374.153695 | - |
dc.identifier.scopusid | 2-s2.0-84926207555 | - |
dc.identifier.wosid | 000353740000027 | - |
dc.identifier.bibliographicCitation | Neural Regeneration Research, v.10, no.3, pp 451 - 456 | - |
dc.citation.title | Neural Regeneration Research | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 451 | - |
dc.citation.endPage | 456 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | ANTIOXIDANT PROTEIN | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | REDUCTASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | nerve regeneration | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.subject.keywordAuthor | dentate gyrus | - |
dc.subject.keywordAuthor | lipid peroxidation | - |
dc.subject.keywordAuthor | type 1 diabetes | - |
dc.subject.keywordAuthor | malondialdehyde | - |
dc.subject.keywordAuthor | neurons | - |
dc.subject.keywordAuthor | neural regeneration | - |
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