Dioscorea batatas Extract Attenuates High-Fat Diet-Induced Obesity in Mice by Decreasing Expression of Inflammatory Cytokines
- Authors
- Gil, Hyo-Wook; Lee, Eun-Young; Lee, Ji-Hye; Kim, Yong-Sik; Lee, Byung-Eui; Suk, Jeong Woo; Song, Ho-Yeon
- Issue Date
- 14-Feb-2015
- Publisher
- Medical Science International Publishing
- Keywords
- Adipogenesis; Diet, High-Fat; Dioscorea; Obesity
- Citation
- Medical Science Monitor, v.21, pp 489 - 495
- Pages
- 7
- Journal Title
- Medical Science Monitor
- Volume
- 21
- Start Page
- 489
- End Page
- 495
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10872
- ISSN
- 1234-1010
1643-3750
- Abstract
- Background: The objective of the present study was to determine whether Dioscorea batatas (DB) extract reduces visceral fat accumulation and obesity-related biomarkers in mice fed a high-fat diet (HFD) and whether genes associated with adipogenesis and inflammation could be modulated by a diet containing DB extract. Material/Methods: Male C57BL/6J mice were divided into 4 groups (n=10 per group): normal diet (ND), HFD, 100 mg/kg DB extract-gavage with HFD, and 200 mg/kg DB extract-gavage with HFD. The mice were fed the experimental diets for 14 weeks. At 12 weeks, micro-computed X-ray tomography (micro-CT) was performed. Results: Supplementation of the diet with DB extract for 14 weeks significantly prevented HFD-induced increases in body weight, visceral adipose tissue, plasma lipid levels, and leptins. The area of visceral fat was reduced by DB extract supplementation when examined by micro-CT. Supplementation with DB extract resulted in the down-regulation of the adipogenic transcription factor (C/ERB alpha) and its target gene (CD36) in epididymal adipose tissue, compared to HFD alone. DB extract decreased the expression of proinflammatory cytokines (TNF-alpha, MCP-1, and IL-6) in epididymal adipose tissue. Conclusions: Our results suggest that DB extract may prevent HFD-induced obesity by downregulating the expression of genes related to adipogenesis and inflammation in visceral adipose tissue.
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Collections - College of Medicine > Department of Microbiology > 1. Journal Articles
- College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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