쇼그렌 증후군 환자에서 작은 침샘 조직검사의 진단적 효용성

Abstract

Background：Sjögren’s syndrome is difficult to diagnose. Because several tools for exact diagnosis have been made over the decades. However none of them is both sensitive and specific. American College of Rheumatology (ACR) issued new diagnostic criteria based on only three objective tests in 2012. These are immunoserologic test, minor salivary gland biopsy, ocular staining test. We analyzed diagnostic effectiveness of minor salivary gland biopsy in suggesting Sjögren’s syndrome patients based on ACR guideline. Methods：We analyze 41 patients who suggesting Sjögren’s syndrome retrospectively about Immunoserologic results, minor salivary gland biopsy results, ocular staining test. Sensitivity and specificity of minor salivary gland biopsy was obtained. Results：Minor salivary gland biopsy sensitivity was 70.8% and specificity, 100%, positive predictive value, 100%, negative predictive value, 70.8%. No salivary gland biopsy complication was noted in 41 patients. Conclusions：Minor salivary gland biopsy is objective test and keyword method for Sjögren’s syndrome final diagnosis. High specificity can help physician to exclude normal people from Sjögren’s syndrome patients. Due to relatively invasive procedure and low sensitivity, this procedure could be recommended to last step for final diagnosis.