DHA의 유방암 세포에 영향Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
- Other Titles
- Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
- Authors
- 황선용; 김태희; 이해혁; 김흥열; 서주현
- Issue Date
- 2015
- Publisher
- 고신대학교 의과대학 학술지
- Keywords
- Apoptosis; breast neoplasms; docosahexaenoic acid; metastasis; proliferation
- Citation
- 고신대학교 의과대학 학술지, v.30, no.2, pp 103 - 107
- Pages
- 5
- Journal Title
- 고신대학교 의과대학 학술지
- Volume
- 30
- Number
- 2
- Start Page
- 103
- End Page
- 107
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11119
- DOI
- 10.7180/kmj.2015.30.2.103
- ISSN
- 2005-9531
2586-7024
- Abstract
- Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer.
Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.
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Collections - College of Medicine > Department of Obstetrics and Gynecology > 1. Journal Articles
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