Atypical Early-Onset Alzheimer’s Disease Dementia Diagnosed by Biomarker StudyAtypical Early-Onset Alzheimer’s Disease Dementia Diagnosed by Biomarker Study
- Other Titles
- Atypical Early-Onset Alzheimer’s Disease Dementia Diagnosed by Biomarker Study
- Authors
- Seung-Keun Lee; Dae-Seop Shin; Ho Sik Shin; Jun-Hyun Kim; 박선아
- Issue Date
- 2015
- Publisher
- 대한치매학회
- Keywords
- amyloid imaging; biomarker; cerebrospinal fluid; early-onset Alzheimer’s disease; positron emission tomography.
- Citation
- Dementia and Neurocognitive Disorders(대한치매학회지), v.14, no.4, pp 168 - 171
- Pages
- 4
- Journal Title
- Dementia and Neurocognitive Disorders(대한치매학회지)
- Volume
- 14
- Number
- 4
- Start Page
- 168
- End Page
- 171
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11125
- DOI
- 10.12779/dnd.2015.14.4.168
- ISSN
- 1738-1495
2384-0757
- Abstract
- Background The described clinical characteristics of early-onset Alzheimer’s disease (EOAD) are distinct from that of late-onset AD. Wereported a patient with atypical EOAD.
Case Report A 54-year-old, truck driver developed gradual visuospatial, language and calculation deficits for 3 months. The neuropsychologicalimpairments were extensive. Brain MRI revealed asymmetric atrophy in left medial temporal lobe along with distinct widening of sylvianfissure. (18)F-florbetapir-positron emission tomography (PET) showed a high uptake in the cortex. Further, the profiles of cerebrospinalfluid (CSF) biomarker were compatible with AD.
Conclusions We diagnosed the patient as EOAD based on the result of biomarker study. Increased Aß burden was identified through amyloidPET imaging and decreased CSF Aβ level. The high rise of CSF Tau proteins was in agreement with the patient’s extensive and rapidcognitive decline. This case report demonstrates the importance of AD biomarker study in confronting early-onset dementia with atypicalclinical presentation.
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