Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APCMin/+ Intestinal Polyposis ModelChemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APCMin/+ Intestinal Polyposis Model
- Other Titles
- Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APCMin/+ Intestinal Polyposis Model
- Authors
- 박미영; 김정미; 김정상; 정명근; 성미경
- Issue Date
- 2015
- Publisher
- 대한암예방학회
- Keywords
- Anthocyanins; APCMin/+; Black soybean; Inflammation; Intestinal tumors
- Citation
- 대한암예방학회지, v.20, no.3, pp.193 - 201
- Journal Title
- 대한암예방학회지
- Volume
- 20
- Number
- 3
- Start Page
- 193
- End Page
- 201
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11227
- ISSN
- 2288-3649
- Abstract
- Background: Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis.
Methods: ApcMin/+ mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, oxidative stress and inflammatory markers associated with β-catenin and cytosolic phospholipase A2 (cPLA2) signals. The number of intestinal tumors, and cellular expression of β-catenin were determined.
Results: The number of intestinal tumors was significantly lower in mice fed a 0.5% AE diet compared to those of the other groups. Cytosolic β-catenin expression was significantly decreased in the AE supplemented groups compared to that of the control animals. In addition, mucosa expression of cyclooxygenase-2 and cPLA2 were also significantly decreased in the 0.5% AE group, by 32% and 62%, respectively, compared to the control group.
Conclusions: These results suggest that dietary AE reduced the development of intestinal tumors, possibly through the ability to suppress oxidative stresses, decreasing inflammatory responses mediated by β-catenin associated signals.
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