Autosomal Translocation Patient Who Experienced Premature Menopause: A Case ReportAutosomal Translocation Patient Who Experienced Premature Menopause: A Case Report
- Other Titles
- Autosomal Translocation Patient Who Experienced Premature Menopause: A Case Report
- Authors
- 김태희; 김예솔; 정도원; 이은경; 전동수; 김준모
- Issue Date
- 2015
- Publisher
- 대한폐경학회
- Keywords
- Autosomal translocation; Premature menopause; Premature Ovarian Failure
- Citation
- 대한폐경학회지, v.21, no.2, pp 112 - 114
- Pages
- 3
- Journal Title
- 대한폐경학회지
- Volume
- 21
- Number
- 2
- Start Page
- 112
- End Page
- 114
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11272
- ISSN
- 2288-6478
2288-6761
- Abstract
- Premature ovarian failure (POF) is a condition in which the ovarian functions of hormone production and oocyte development become impaired before the typical age for menopause. POF and early menopause are present in a broad spectrum of gonad dysgenesis, from a complete cessation of ovarian function to an intermittent follicle maturation failure. Actually POF has been identified as a genetic entity (especially chromosome X), but data on genetic factors of premature menopause are limited. Until now, several cases revealed that inactivation of X chromosomes has an effect on ages of premature menopause and females with balanced or unbalanced X-autosome translocations can have several reproductive problems. On the other hand, there have been a few data that was caused by autosome-autosome translocation can lead. Therefore we report a relevant case of POF with translocation between chromosomes 1 and 4. She had her first menstrual period at the age of 12, and after 7 years she stopped menstruation. Chromosomal analysis showed 46, XX, t (1;4) (p22.3;q31.3). While evaluating this rare case, we could review various causes (especially genetic factors) of POF. To remind clinicians about this disease, we report a case of POF caused by autosome-autosome translocation with a literature review. (J Menopausal Med 2015;21:112-114)
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Collections - College of Medicine > Department of Urology > 1. Journal Articles
- College of Medicine > Department of Obstetrics and Gynecology > 1. Journal Articles
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