Effects of ischemic preconditioning on VEGF and pFlk-1 immunoreactivities in the gerbil ischemic hippocampus after transient cerebral ischemia
DC Field | Value | Language |
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dc.contributor.author | Park, Yoo Seok | - |
dc.contributor.author | Cho, Jun Hwi | - |
dc.contributor.author | Kim, In Hye | - |
dc.contributor.author | Cho, Geum-Sil | - |
dc.contributor.author | Cho, Jeong-Hwi | - |
dc.contributor.author | Park, Joon Ha | - |
dc.contributor.author | Ahn, Ji Hyeon | - |
dc.contributor.author | Chen, Bai Hui | - |
dc.contributor.author | Shin, Bich-Na | - |
dc.contributor.author | Shin, Myoung Cheol | - |
dc.contributor.author | Tae, Hyun-Jin | - |
dc.contributor.author | Cho, Young Shin | - |
dc.contributor.author | Lee, Yun Lyul | - |
dc.contributor.author | Kim, Young-Myeong | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.contributor.author | Lee, Jae-Chul | - |
dc.date.accessioned | 2021-08-11T21:45:26Z | - |
dc.date.available | 2021-08-11T21:45:26Z | - |
dc.date.issued | 2014-12-15 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.issn | 1878-5883 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11561 | - |
dc.description.abstract | Ischemia preconditioning (IPC) displays an important adaptation of the CNS to sub-lethal ischemia. In the present study, we examined the effect of IPC on immunoreactivities of VEGF-, and phospho-Flk-1 (pFlk-1) following transient cerebral ischemia in gerbils. The animals were randomly assigned to four groups (sham-operated-group, ischemia-operated-group, IPC plus (+) sham-operated-group, and IPC + ischemia-operated-group). IPC was induced by subjecting gerbils to 2 min of ischemia followed by 1 day of recovery. In the ischemia-operated-group, a significant loss of neurons was observed in the stratum pyramidale (SP) of the hippocampal CM region (CA1) alone 5 days after ischemia-reperfusion, however, in all the IPC + ischemia-operated-groups, pyramidal neurons in the SP were well protected. In immunohistochemical study, VEGF immunoreactivity in the ischemia-operated-group was increased in the SP at 1 day post-ischemia and decreased with time. Five days after ischemia-reperfusion, strong VEGF immunoreactivity was found in non-pyramidal cells, which were identified as pericytes, in the stratum oriens (SO) and radiatum (SR). In the IPC + sham-operated- and IPC + ischemia-operated-groups, VEGF immunoreactivity was significantly increased in the SP. pFlk-1 immunoreactivity in the sham-operated- and ischemia-operated-groups was hardly found in the SP, and, from 2 days post-ischemia, pFlk-1 immunoreactivity was strongly increased in non-pyramidal cells, which were identified as pericytes. In the IPC + sham-operated-group, pFlk-1 immunoreactivity was significantly increased in both pyramidal and non-pyramidal cells; in the IPC + ischemia-operated-groups, the similar pattern of VEGF immunoreactivity was found in the ischemic CM, although the VEGF immunoreactivity was strong in non-pyramidal cells at 5 days post-ischemia. In brief, our findings show that IPC dramatically augmented the induction of VEGF and pFlk-1 immunoreactivity in the pyramidal cells of the CA1 after ischemia-reperfusion, and these findings suggest that the increases of VEGF and Flk-1 expressions may be necessary for neurons to survive from transient ischemic damage. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Effects of ischemic preconditioning on VEGF and pFlk-1 immunoreactivities in the gerbil ischemic hippocampus after transient cerebral ischemia | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jns.2014.09.044 | - |
dc.identifier.wosid | 000347576500026 | - |
dc.identifier.bibliographicCitation | Journal of the Neurological Sciences, v.347, no.1-2, pp 179 - 187 | - |
dc.citation.title | Journal of the Neurological Sciences | - |
dc.citation.volume | 347 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 187 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | BLOOD-BRAIN-BARRIER | - |
dc.subject.keywordPlus | STIMULATES AXONAL OUTGROWTH | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SELECTIVE VULNERABILITY | - |
dc.subject.keywordPlus | FACTOR EXPRESSION | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | ISCHEMIA/REPERFUSION INJURY | - |
dc.subject.keywordPlus | FACTOR RECEPTORS | - |
dc.subject.keywordPlus | NEURONAL DAMAGE | - |
dc.subject.keywordAuthor | Ischemia-reperfusion | - |
dc.subject.keywordAuthor | Ischemic preconditioning | - |
dc.subject.keywordAuthor | Delayed neuronal death | - |
dc.subject.keywordAuthor | Vascular endothelial growth factor | - |
dc.subject.keywordAuthor | Phospho-Flk-1 | - |
dc.subject.keywordAuthor | Pericytes | - |
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