Down-regulation of MAPK/NF-kappa KB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model
DC Field | Value | Language |
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dc.contributor.author | Jeong, Hoon Jae | - |
dc.contributor.author | Park, Meeyoung | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Ryu, Eun Ji | - |
dc.contributor.author | Yong, Ji In | - |
dc.contributor.author | Cha, Hyun Ju | - |
dc.contributor.author | Kim, Sang Jin | - |
dc.contributor.author | Yeo, Hyeon Ji | - |
dc.contributor.author | Jeong, Ji-Heon | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Kim, Hyoung Chun | - |
dc.contributor.author | Shin, Eun Joo | - |
dc.contributor.author | Park, Eun Young | - |
dc.contributor.author | Park, Jong Hoon | - |
dc.contributor.author | Kwon, Hyeok Yil | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-11T21:46:05Z | - |
dc.date.available | 2021-08-11T21:46:05Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.issn | 1878-1705 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11655 | - |
dc.description.abstract | Excessive reactive oxygen species (ROS) production plays a crucial role in causing various diseases, including inflammatory disorders. The activation of mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB (NF-kappa B) signaling is implicated in stimulating inflammatory response and cytokines. Peroxiredoxin 2 (Prx2) is a 2-cysteine (Cys) peroxiredoxin capable of removing endogenous hydrogen peroxide (H2O2). PEP-1 peptide, a protein transduction domain, consists of three domains which are used to transduce exogenous therapeutic proteins into cells. The correlation between effectively transduced PEP-1-Prx2 and ROS-mediated inflammatory response is not clear. In the present study, we investigated the protective effects of cell permeable PEP-1-Prx2 on oxidative stress-induced inflammatory activity in Raw 264.7 cells and in a mouse ear edema model after exposure to lipopolysaccharides (LPS) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Transduced PEP-1-Prx2 suppressed intracellular ROS accumulation and inhibited the activity of MAPKs and NF-kappa B signaling that led to the suppression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and cytokines in LPS-induced Raw 264.7 cells and TPA-induced mouse ear edema model. Given these results, we propose that PEP-1-Prx2 has therapeutic potential in the prevention of inflammatory disorders. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Down-regulation of MAPK/NF-kappa KB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.intimp.2014.09.008 | - |
dc.identifier.scopusid | 2-s2.0-84912065005 | - |
dc.identifier.wosid | 000346954000008 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, v.23, no.2, pp 426 - 433 | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 426 | - |
dc.citation.endPage | 433 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | NEURONAL CELL-DEATH | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | SKIN INFLAMMATION | - |
dc.subject.keywordPlus | PEROXIREDOXIN-II | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MAMMALIAN PEROXIREDOXIN | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | PEP-1-Prx2 | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Protein therapy | - |
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