CDr10b inhibits the expression of cyclooxygenase-2 and inducible nitric oxide synthase induced by lipopolysaccharide
DC Field | Value | Language |
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dc.contributor.author | Gu, Gyo-Jeong | - |
dc.contributor.author | Lim, Se-Jin | - |
dc.contributor.author | Ahn, Sang-il | - |
dc.contributor.author | Lee, Sung-Chan | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.contributor.author | Choi, Tae Hyun | - |
dc.contributor.author | Kim, Byoung Soo | - |
dc.contributor.author | Eom, Yong-Bin | - |
dc.contributor.author | Lee, Na Kyung | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-11T21:46:49Z | - |
dc.date.available | 2021-08-11T21:46:49Z | - |
dc.date.issued | 2014-11-05 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11701 | - |
dc.description.abstract | The pathophysiological processes of inflammation can lead to a host of diseases, such as periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer. The dysregulated inducible nitric oxide synthase ( iNOS) and cyclooxygenase-2 ( COX- 2) activation play important roles in the development of certain inflammatory diseases. Here, we investigated the effects of CDr10b which is originally developed for a microglia staining probe on inflammation, by modulating NF-kappa B activation and iNOS and COX-2 expression induced by lipopolysaccharide (LPS) in murine macrophages. The CDr10b suppressed NF-kappa B activation and iNOS and COX-2 expression induced by LPS. All the results suggest that CDr10b is a promising novel agent for the treatment of inflammatory diseases. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | CDr10b inhibits the expression of cyclooxygenase-2 and inducible nitric oxide synthase induced by lipopolysaccharide | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.ejphar.2014.08.036 | - |
dc.identifier.scopusid | 2-s2.0-84922242002 | - |
dc.identifier.wosid | 000345526600006 | - |
dc.identifier.bibliographicCitation | European Journal of Pharmacology, v.742, pp 42 - 46 | - |
dc.citation.title | European Journal of Pharmacology | - |
dc.citation.volume | 742 | - |
dc.citation.startPage | 42 | - |
dc.citation.endPage | 46 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TLR4 | - |
dc.subject.keywordPlus | HOMODIMERIZATION | - |
dc.subject.keywordPlus | PHYTOCHEMICALS | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Nuclearfactor-kappa B | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Inducible nitric oxide synthase | - |
dc.subject.keywordAuthor | CDr10b | - |
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