An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4(+) T Cells Controls Obesity-Induced Inflammation
DC Field | Value | Language |
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dc.contributor.author | Cho, Kae Won | - |
dc.contributor.author | Morris, David L. | - |
dc.contributor.author | DelProposto, Jennifer L. | - |
dc.contributor.author | Geletka, Lynn | - |
dc.contributor.author | Zamarron, Brian | - |
dc.contributor.author | Martinez-Santibanez, Gabriel | - |
dc.contributor.author | Meyer, Kevin A. | - |
dc.contributor.author | Singer, Kanakadurga | - |
dc.contributor.author | O'Rourke, Robert W. | - |
dc.contributor.author | Lumeng, Carey N. | - |
dc.date.accessioned | 2021-08-11T22:24:47Z | - |
dc.date.available | 2021-08-11T22:24:47Z | - |
dc.date.issued | 2014-10-23 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11770 | - |
dc.description.abstract | An adaptive immune response triggered by obesity is characterized by the activation of adipose tissue CD4(+) T cells by unclear mechanisms. We have examined whether interactions between adipose tissue macrophages (ATMs) and CD4(+) T cells contribute to adipose tissue metainflammation. Intravital microscopy identifies dynamic antigen-dependent interactions between ATMs and T cells in visceral fat. Mice deficient in major histocompatibility complex class II (MHC II) showed protection from diet-induced obesity. Deletion of MHC II expression in macrophages led to an adipose tissue-specific decrease in the effector/memory CD4(+) T cells, attenuation of CD11c(+) ATM accumulation, and improvement in glucose intolerance by increasing adipose tissue insulin sensitivity. Ablation experiments demonstrated that the maintenance of proliferating conventional T cells is dependent on signals from CD11c(+) ATMs in obese mice. These studies demonstrate the importance of MHCII-restricted signals from ATMs that regulate adipose tissue T cell maturation and metainflammation. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Cell Press | - |
dc.title | An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4(+) T Cells Controls Obesity-Induced Inflammation | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.celrep.2014.09.004 | - |
dc.identifier.scopusid | 2-s2.0-84919875183 | - |
dc.identifier.wosid | 000344469100020 | - |
dc.identifier.bibliographicCitation | Cell Reports, v.9, no.2, pp 605 - 617 | - |
dc.citation.title | Cell Reports | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 605 | - |
dc.citation.endPage | 617 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ANTIGEN-PRESENTING CELLS | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | TH1 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | adipose tissue inflmammation | - |
dc.subject.keywordAuthor | macrophage | - |
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