Passive heat loading links lipolysis and regulation of fibroblast growth factor-21 in humans
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeong-Beom | - |
dc.contributor.author | Kim, Tae-Wook | - |
dc.date.accessioned | 2021-08-11T22:24:59Z | - |
dc.date.available | 2021-08-11T22:24:59Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 0306-4565 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11805 | - |
dc.description.abstract | There is relativley little information on the serum biomarkers of heat stress. Therefore, the goal of this study was to verify the effect of passive heat loading (PHL) on the expression of fibroblast growth factor-21 (FGF21) and free fatty acids (FFAs). Four PHL protocols based on intensity (39 degrees C vs. 43 degrees C, leg immersion, 30 min) and type (leg vs. half immersion, 42 degrees C, 30 min) were used. Each protocol was applied on a 2 day cycle to 12 healthy adult males (age, 22.4 +/- 2.9 years: height, 174.1 +/- 4.6 cm; weight, 71.3 +/- 5.6 kg: body mass index, 23.1 +/- 3.0). The subjects were categorized into two groups according to the study design (randomized, with a parallel trial). Body temperature, FGF21 and FFAs were determined prior to PHL, immediately and 60 min after PHI., Body temperature was significant higher (43 degrees C) than the 39 degrees C measured under identical PHL type (leg immersion). PHL was effective for the expression of FGF21 and for lipolysis. The quantitative levels of FGF21 and FFA increased with increasing temperature (39 degrees C < 42 degrees C < 43 degrees C). A significant difference in the quantitative levels of FGF21 and FFAs was also evident based on the type of PHL (leg < half immersion) even when PHL was applied at the same temperature (42 degrees C). In conclusion, PHL was effective for expressing FGF21 and for lipolysis. Therefore. PHL may be expected to help in the reduction of body fat, Additionally, when the identical type (leg immersion) of PHL is applied, a loading temperature of 43 degrees C is more effective for expressing FGF21 and for lipolysis than temperatures of 39 degrees C and 42 degrees C, and half immersion is more effective than leg immersion at 42 degrees C. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Passive heat loading links lipolysis and regulation of fibroblast growth factor-21 in humans | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.jtherbio.2014.09.004 | - |
dc.identifier.scopusid | 2-s2.0-84907553418 | - |
dc.identifier.wosid | 000359750300023 | - |
dc.identifier.bibliographicCitation | Journal of Thermal Biology, v.45, pp 163 - 167 | - |
dc.citation.title | Journal of Thermal Biology | - |
dc.citation.volume | 45 | - |
dc.citation.startPage | 163 | - |
dc.citation.endPage | 167 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.subject.keywordPlus | SWEATING SENSITIVITY | - |
dc.subject.keywordPlus | METABOLIC ACTIONS | - |
dc.subject.keywordPlus | FGF21 | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.subject.keywordAuthor | FGF21 | - |
dc.subject.keywordAuthor | Lipolysis | - |
dc.subject.keywordAuthor | Passive heat loading | - |
dc.subject.keywordAuthor | Leg immersion | - |
dc.subject.keywordAuthor | Half immersion | - |
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