Epidemiological Aspects of Pertussis among Adults and Adolescents in a Korean Outpatient Setting: A Multicenter, PCR-Based Study
- Authors
- Park, Sunghoon; Lee, Sun Hwa; Seo, Ki-Hyun; Shin, Kyeong-Cheol; Park, Yong Bum; Lee, Myung Goo; Yoo, Kwang Ha; Kim, Hui Jung; Park, Jae Seuk; Cho, Jae Hwa; Ko, Yongchun; Lee, Soo-Keol; Cheon, Ki Tae; Kim, Do Il; Ha, Jun Wook; Lee, Jae-Myung; Suhr, Ji-Won; Jeong, Eui Hun; Jung, Ki-Suck
- Issue Date
- Sep-2014
- Publisher
- 대한의학회
- Keywords
- Pertussis; Adult; Hospitals; Incidence; Seasons
- Citation
- Journal of Korean Medical Science, v.29, no.9, pp 1232 - 1239
- Pages
- 8
- Journal Title
- Journal of Korean Medical Science
- Volume
- 29
- Number
- 9
- Start Page
- 1232
- End Page
- 1239
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11885
- DOI
- 10.3346/jkms.2014.29.9.1232
- ISSN
- 1011-8934
1598-6357
- Abstract
- Epidemiological data of Bordetella pertussis infection among adolescents and adults are limited in Korea. Patients (>= 11 yr of age) with a bothersome cough for less than 30 days were enrolled during a 1-yr period at 22 hospitals in Korea. Nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and for bacteriologic culture. In total, 490 patients were finally enrolled, and 34 (6.9%) patients tested positive for B. pertussis; cough duration (14.0 days [7.0-21.0 days]) and age distribution were diverse. The incidence was the highest in secondary referral hospitals, compared to primary care clinics or tertiary referral hospitals (24/226 [10.6%] vs. 3/88 [3.4%] vs. 7/176 [4.0%], P = 0.012), and the peak incidence was observed in February and August (15.8% and 15.9%), with no confirmed cases between March and June. In the multivariate analysis, post-tussive vomiting was significantly associated with pertussis (odds ratio, 2.508; 95% confidence interval, 1.146-5.486) and secondary referral hospital showed a borderline significance. In conclusion, using a PCR-based method, 6.9% of adolescent and adult patients with an acute cough illness had pertussis infection in an outpatient setting. However, hospital levels and seasonal trends must be taken into account to develop a better strategy for controlling pertussis.
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