The role of wogonin in controlling SOCS3 expression in neuronal cells
DC Field | Value | Language |
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dc.contributor.author | Nam, Kung-Woo | - |
dc.contributor.author | Chae, Sungwook | - |
dc.contributor.author | Song, Ho-Yeon | - |
dc.contributor.author | Mar, Woongchon | - |
dc.contributor.author | Han, Man-Deuk | - |
dc.date.accessioned | 2021-08-11T22:26:53Z | - |
dc.date.available | 2021-08-11T22:26:53Z | - |
dc.date.issued | 2014-08-08 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11948 | - |
dc.description.abstract | The mechanism underlying the wogonin-mediated increase in the expression of suppressor of cytokine signaling 3 (SOCS3) is unclear. Promoter deletion assay results revealed that wogonin-induced SOCS3 expression is dependent on the AP-1 consensus sequences and two STAT responsive elements (TTACAAGAA and TTCCAGGAA) in the 5'-flanking region of the SOCS3 gene in SH-SY5Y cells. Wogonin-induced SOCS3 expression was blocked by inhibitors of PI3K, Akt, Raf, p38, JNK, MEK, and STAT3, respectively. However, JAK2 inhibitors did not inhibit wogonin-induced SOCS3 expression. These results indicate that SOCS3-inducing effect of wogonin is caused by the activation of PI3K-mediated MAPK signaling pathways (Akt, ERK1/2, p38, and JNK), and the subsequent activation of AP-1 consensus sequences and STAT responsive elements in SH-SY5Y cells. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press | - |
dc.title | The role of wogonin in controlling SOCS3 expression in neuronal cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2014.07.018 | - |
dc.identifier.scopusid | 2-s2.0-84906086531 | - |
dc.identifier.wosid | 000341338100047 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.450, no.4, pp 1518 - 1524 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 450 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1518 | - |
dc.citation.endPage | 1524 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | CYTOKINE SIGNALING 3 | - |
dc.subject.keywordPlus | CEREBRAL-ARTERY OCCLUSION | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | INFLAMMATORY ARTHRITIS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | TRANSDUCER | - |
dc.subject.keywordAuthor | Wogonin | - |
dc.subject.keywordAuthor | SOCS3 | - |
dc.subject.keywordAuthor | Neuroinflammation | - |
dc.subject.keywordAuthor | PI3K | - |
dc.subject.keywordAuthor | AP1 | - |
dc.subject.keywordAuthor | STAT3 | - |
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