Soluble alpha-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes
DC Field | Value | Language |
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dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Kim, Sang Soo | - |
dc.contributor.author | Lee, Ji-Sung | - |
dc.contributor.author | Kim, In Joo | - |
dc.contributor.author | Song, Sang Heon | - |
dc.contributor.author | Cha, Seung-Kuy | - |
dc.contributor.author | Park, Kyu-Sang | - |
dc.contributor.author | Kang, Jeong Suk | - |
dc.contributor.author | Chung, Choon Hee | - |
dc.date.accessioned | 2021-08-11T22:26:54Z | - |
dc.date.available | 2021-08-11T22:26:54Z | - |
dc.date.issued | 2014-08-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11949 | - |
dc.description.abstract | Objective: Although alpha-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble alpha-klotho levels in patients with diabetes have not been evaluated. Therefore, this study evaluated whether plasma and urinary alpha-klotho levels are associated with albuminuria in kidney disease in diabetes. Research Design and Methods: A total of 147 patients with type 2 diabetes and 25 healthy control subjects were enrolled. The plasma and urine concentrations of alpha-klotho were analyzed by enzyme-linked immunosorbent assay. Results: Plasma alpha-klotho (572.4 pg/mL [95% CI, 541.9-604.6 pg/mL] vs. 476.9 pg/mL [95% CI, 416.9-545.5 pg/mL]) and urinary alpha-klotho levels (59.8 pg/mg creatinine [95% CI, 43.6-82.0 pg/mg creatinine] vs. 21.0 pg/mg creatinine [95% CI, 9.7-45.6 pg/mg creatinine]) were significantly higher in diabetic patients than non-diabetic controls. Among diabetic patients, plasma alpha-klotho concentration was inversely associated with albuminuria stages (normoalbuminuria, 612.6 pg/mL [95% CI, 568.9-659.6 pg/mL], microalbuminuria, 551.8 pg/mL [95% CI, 500.5-608.3 pg/mL], and macroalbuminuria, 505.7 pg/mL [95% CI, 439.7-581.7 pg/mL] (p for trend = 0.0081), while urinary alpha-klotho levels were remained constantly high with increasing urinary albumin excretion. Conclusions: Soluble alpha-klotho levels in plasma and urine may be novel and useful early markers of diabetic renal injury. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Public Library of Science | - |
dc.title | Soluble alpha-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1371/journal.pone.0102984 | - |
dc.identifier.scopusid | 2-s2.0-84905384708 | - |
dc.identifier.wosid | 000339819800013 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.9, no.8 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 8 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | TRPV5 CHANNEL | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | EXCRETION | - |
dc.subject.keywordPlus | URINARY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | 당뇨 | - |
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