Loading dose vs. maintenance dose of warfarin for reinitiation after invasive procedures: a randomized trial
DC Field | Value | Language |
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dc.contributor.author | Schulman, S. | - |
dc.contributor.author | Hwang, H. -G. | - |
dc.contributor.author | Eikelboom, J. W. | - |
dc.contributor.author | Kearon, C. | - |
dc.contributor.author | Pai, M. | - |
dc.contributor.author | Delaney, J. | - |
dc.date.accessioned | 2021-08-11T22:44:02Z | - |
dc.date.available | 2021-08-11T22:44:02Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1538-7933 | - |
dc.identifier.issn | 1538-7836 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12012 | - |
dc.description.abstract | Background: There is uncertainty regarding the optimal dosing regimen for the resumption of warfarin after interruption for invasive procedures. Aim: To determine the efficacy and safety of warfarin resumption with loading doses or with the most recent maintenance dose. Methods: Patients receiving warfarin treatment and planned for invasive procedures with an expected hospital stay of <= 1 day were randomized to resume warfarin on the day of the procedure, defined as day 1, with most recent maintenance dose or with 2 initial days of double maintenance dose. Efficacy outcomes were proportion of international normalized ratio (INR) levels >= 2.0 on day 5 (primary outcome) and day 10. Safety outcomes were bleeding and thromboembolic events. In addition, D-dimer levels were analyzed on days 5 and 10 in a subset of the population. Results: There were 49 patients analyzed in each group. INR of >= 2.0 had been achieved by day 5 for 13% in the maintenance-dose group and for 50% in the loading-dose group (relative risk [RR] 0.27, 95% confidence interval [CI] 0.10-0.60) and by day 10 for 68% and 87%, respectively (RR 0.78, 95% CI 0.65-1.00). There were no thromboembolic events, and there was one major bleed before resumption of warfarin and one minor bleed, both in the maintenance-dose group. There was no difference between the groups in the proportion of patients with excessive INRs or elevated D-dimer levels or in the median D-dimer level. Conclusion: Resumption of warfarin after minor-moderately invasive procedures with two loading doses achieves therapeutic INR faster than does only maintenance dose. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Loading dose vs. maintenance dose of warfarin for reinitiation after invasive procedures: a randomized trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/jth.12613 | - |
dc.identifier.scopusid | 2-s2.0-84905684580 | - |
dc.identifier.wosid | 000342142700010 | - |
dc.identifier.bibliographicCitation | Journal of Thrombosis and Haemostasis, v.12, no.8, pp 1254 - 1259 | - |
dc.citation.title | Journal of Thrombosis and Haemostasis | - |
dc.citation.volume | 12 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1254 | - |
dc.citation.endPage | 1259 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | ATRIAL-FIBRILLATION | - |
dc.subject.keywordPlus | ORAL ANTICOAGULATION | - |
dc.subject.keywordPlus | INITIATION | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | 5-MG | - |
dc.subject.keywordAuthor | anticoagulation | - |
dc.subject.keywordAuthor | bleeding | - |
dc.subject.keywordAuthor | D-dimer | - |
dc.subject.keywordAuthor | international normalized ratio | - |
dc.subject.keywordAuthor | surgery | - |
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