Distinct regulatory effect of the p34(SEI-1) oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells
DC Field | Value | Language |
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dc.contributor.author | Jung, Samil | - |
dc.contributor.author | Ohk, Jiyeon | - |
dc.contributor.author | Jeong, Dongjun | - |
dc.contributor.author | Li, Chengping | - |
dc.contributor.author | Lee, Soonduck | - |
dc.contributor.author | Duan, Jingjing | - |
dc.contributor.author | Kim, Changjin | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Kim, Keun-Il | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.accessioned | 2021-08-11T22:44:38Z | - |
dc.date.available | 2021-08-11T22:44:38Z | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.issn | 1791-2423 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12063 | - |
dc.description.abstract | The p34(SEI-1) oncoprotein is involved in a transcriptional regulation, cell cycle regulation, apoptosis, development and many other important cellular functions. Our present study suggests that p34(SEI-1) can promote metastasis by enhancing migration and invasion of cancer cells. Consistently, p34(SEI-1) expression was found to be increased as the tumor invasiveness progressed in human breast tissues. p34(SEI-1) may promote cancer metastasis by activating the PI3K/AKT signaling pathway. In this process, p34(SEI-1) activates two different serine/threonine kinases, AKT or ILK, depending on the expression status of HER2/neu oncogene. In HER2/neu suppressed cancer cells, p34(SEI-1) promoted metastasis mainly by activating AKT via phosphorylation of the 473 serine residue. In HER2/neu expressing cancer cells, p34(SEI-1) overexpression downregulates HER2/neu expression, leading to the activation of another crucial serine/threonine kinase ILK due to phosphorylation of the 178 threonine residue instead of AKT. These results suggest that p34(SEI-1) affects cancer metastasis by regulating two different signaling pathways depending on the HER2/neu expression level, in which AKT and ILK modulation can be stimulated by p34(SEI-1) overexpression. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Demetrios A. Spandidos Ed. & Pub. | - |
dc.title | Distinct regulatory effect of the p34(SEI-1) oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/ijo.2014.2403 | - |
dc.identifier.scopusid | 2-s2.0-84902588308 | - |
dc.identifier.wosid | 000336881600021 | - |
dc.identifier.bibliographicCitation | International Journal of Oncology, v.45, no.1, pp 189 - 196 | - |
dc.citation.title | International Journal of Oncology | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 189 | - |
dc.citation.endPage | 196 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | INTEGRIN-LINKED KINASE | - |
dc.subject.keywordPlus | PI3K/AKT/MTOR PATHWAY | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | PTEN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TUMORIGENESIS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | 34-kD protein encoding SEI-1 gene | - |
dc.subject.keywordAuthor | human epidermal growth factor receptor 2 | - |
dc.subject.keywordAuthor | phosphoinositide-3 kinase/serine/threonine-specific protein kinase | - |
dc.subject.keywordAuthor | integrin-linked kinase | - |
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