In Vitro and In Vivo Evaluation of Composite Scaffold of BCP, Bioglass and Gelatin for Bone Tissue Engineering
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Woo Seok | - |
dc.contributor.author | Nath, Subrata Deb | - |
dc.contributor.author | Bae, Jun Sang | - |
dc.contributor.author | Padalhin, Andrew | - |
dc.contributor.author | Kim, Boram | - |
dc.contributor.author | Song, Myeong Jin | - |
dc.contributor.author | Min, Young Ki | - |
dc.date.accessioned | 2021-08-11T22:45:50Z | - |
dc.date.available | 2021-08-11T22:45:50Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1225-0562 | - |
dc.identifier.issn | 2287-7258 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12172 | - |
dc.description.abstract | In this experiment, a highly porous scaffold of biphasic calcium phosphate (BCP) was prepared using the spongereplica method. The BCP scaffold was coated with 58S bioactive glass (BG) and sintered for a second time. The resulting scaffold was coated with gelatin (Gel) and cross-linked with [3-(3-dimethyl aminopropyl) carbodiimide] and NHydroxysuccinamide( EDC-NHS). The initial average pore size of the scaffold ranged from 300 to 700 mu m, with more than 85 % porosity. The coating of BG and Gel had a significant effect on the scaffold-pore size, decreasing scaffold porosity while increasing mechanical strength. The material and surface properties were evaluated by means of several experiments involving scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) and X-ray diffraction (XRD). Cytotoxicity was evaluated using MTT assay and confocal imaging of MC3T3-E1pre- osteoblast cells cultured in vitro. Three types of scaffold (BCP, BCPBG and BCP-BG-Gel) were implanted in a rat skull for in vivo evaluation. After 8 weeks of implantation, bone regeneration occurred in all three types of sample. Interestingly, regeneration was found to be greater ( geometrically and physiologically) for neat BCP scaffolds than for two other kinds of composite scaffolds. However, the other two types of scaffolds were still better than the control (i.e., defect without treatment). | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국재료학회 | - |
dc.title | In Vitro and In Vivo Evaluation of Composite Scaffold of BCP, Bioglass and Gelatin for Bone Tissue Engineering | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3740/MRSK.2014.24.6.310 | - |
dc.identifier.scopusid | 2-s2.0-84908614574 | - |
dc.identifier.wosid | 000421300100006 | - |
dc.identifier.bibliographicCitation | 한국재료학회지, v.24, no.6, pp 310 - 318 | - |
dc.citation.title | 한국재료학회지 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 310 | - |
dc.citation.endPage | 318 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001887083 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | CALCIUM-PHOSPHATE CEMENT | - |
dc.subject.keywordPlus | BIOACTIVE GLASS | - |
dc.subject.keywordPlus | BIOCOMPATIBILITY | - |
dc.subject.keywordAuthor | sponge replica | - |
dc.subject.keywordAuthor | BCP | - |
dc.subject.keywordAuthor | bioglass | - |
dc.subject.keywordAuthor | gelatin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.