Efficacy and Safety of Weekly Alendronate Plus Vitamin D-3 5600 IU versus Weekly Alendronate Alone in Korean Osteoporotic Women: 16-Week Randomized Trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kwang Joon | - |
dc.contributor.author | Min, Yong-Ki | - |
dc.contributor.author | Koh, Jung-Min | - |
dc.contributor.author | Chung, Yoon-Sok | - |
dc.contributor.author | Kim, Kyoung Min | - |
dc.contributor.author | Byun, Dong-Won | - |
dc.contributor.author | Kim, In Joo | - |
dc.contributor.author | Kim, Mikyung | - |
dc.contributor.author | Kim, Sung-Soo | - |
dc.contributor.author | Min, Kyung Wan | - |
dc.contributor.author | Han, Ki Ok | - |
dc.contributor.author | Park, Hyoung Moo | - |
dc.contributor.author | Shin, Chan Soo | - |
dc.contributor.author | Choi, Sung Hee | - |
dc.contributor.author | Park, Jong Suk | - |
dc.contributor.author | Chung, Dong Jin | - |
dc.contributor.author | Mok, Ji Oh | - |
dc.contributor.author | Baek, Hong Sun | - |
dc.contributor.author | Moon, Seong-Hwan | - |
dc.contributor.author | Kim, Yong Soo | - |
dc.contributor.author | Lim, Sung-Kil | - |
dc.date.accessioned | 2021-08-11T22:46:18Z | - |
dc.date.available | 2021-08-11T22:46:18Z | - |
dc.date.issued | 2014-05-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.issn | 1976-2437 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12202 | - |
dc.description.abstract | Vitamin D (vit-D) is essential for bone health, although many osteoporosis patients have low levels of 25-hydroxy-vit-D [25(OH)D]. This randomized, open-label study compared the effects of once weekly alendronate 70 mg containing 5600 IU vit-D-3 (ALN/D5600) to alendronate 70 mg without additional vit-D (ALN) on the percent of patients with vit-D insufficiency [25(OH)D <15 ng/mL, primary end-point] and serum parathyroid hormone (PTH, secondary endpoint) levels in postmenopausal, osteoporotic Korean women. Neuromuscular function was also measured. A total of 268 subjects were randomized. Overall, 35% of patients had vit-D insufficiency at baseline. After 16-weeks, there were fewer patients with vit-D insufficiency in the ALN/D5600 group (1.47%) than in the ALN group (41.67%) (p<0.001). Patients receiving ALN/D5600 compared with ALN were at a significantly decreased risk of vit-D insufficiency [odds ratio=0.02, 95% confidence interval (CI) 0.00-0.08]. In the ALN/D5600 group, significant increases in serum 25(OH)D were observed at weeks 8 (9.60 ng/mL) and 16 (11.41 ng/mL), where as a significant decrease was recorded in the ALN group at week 16 (-1.61 ng/mL). By multiple regression analysis, major determinants of increases in serum 25(OH) D were ALN/D5600 administration, seasonal variation, and baseline 25(OH)D. The least squares mean percent change from baseline in serum PTH in the ALN/D5600 group (8.17%) was lower than that in the ALN group (29.98%) (p=0.0091). There was no significant difference between treatment groups in neuromuscular function. Overall safety was similar between groups. In conclusion, the administration of 5600 IU vit-D in the ALN/D5600 group improved vit-D status and reduced the magnitude of PTH increase without significant side-effects after 16 weeks in Korean osteoporotic patients. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 연세대학교의과대학 | - |
dc.title | Efficacy and Safety of Weekly Alendronate Plus Vitamin D-3 5600 IU versus Weekly Alendronate Alone in Korean Osteoporotic Women: 16-Week Randomized Trial | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3349/ymj.2014.55.3.715 | - |
dc.identifier.scopusid | 2-s2.0-84898716070 | - |
dc.identifier.wosid | 000334820700022 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, v.55, no.3, pp 715 - 724 | - |
dc.citation.title | Yonsei Medical Journal | - |
dc.citation.volume | 55 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 715 | - |
dc.citation.endPage | 724 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001870707 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | LOWER-EXTREMITY FUNCTION | - |
dc.subject.keywordPlus | D INADEQUACY | - |
dc.subject.keywordPlus | D SUPPLEMENTATION | - |
dc.subject.keywordPlus | CONTINUOUS PTH | - |
dc.subject.keywordPlus | FRACTURE | - |
dc.subject.keywordPlus | BISPHOSPHONATES | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Alendronate | - |
dc.subject.keywordAuthor | vitamin-D | - |
dc.subject.keywordAuthor | vitamin-D insufficiency | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | parathyroid hormone | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.