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Naringenin Exerts Cytoprotective Effect Against Paraquat-Induced Toxicity in Human Bronchial Epithelial BEAS-2B Cells Through NRF2 Activation

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dc.contributor.authorPodder, Biswajit-
dc.contributor.authorSong, Ho-Yeon-
dc.contributor.authorKim, Yong-Sik-
dc.date.accessioned2021-08-11T22:46:28Z-
dc.date.available2021-08-11T22:46:28Z-
dc.date.issued2014-05-
dc.identifier.issn1017-7825-
dc.identifier.issn1738-8872-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12225-
dc.description.abstractWe have previously shown that paraquat (PQ)-induced oxidative stress causes dramatic damage in various human cell lines. Naringenin (NG) is an active flavanone, which has been reported to have beneficial bioactivities, including antioxidative, anti-inflammatory, and antitumorigenic activities, with a relatively low toxicity to normal cells. In this study, we intended to assess the cytoprotective effect of NG against PQ-induced toxicity in the human bronchial epithelial BEAS-2B cell line. Co-treatment with NG in PQ-treated BEAS-2B cells can reduce PQ-induced cellular toxicity. NG can also decrease the generation of intracellular ROS caused by PQ treatment. We also observed that treatment with NG in PQ-exposed BEAS-2B cells can significantly induce the expression of antioxidant-related genes, including GPX2, GPX3, GPX5, and GPX7. NG co-treatment can also activate the NRF2 transcription factor and promote its nuclear translocation. In addition, NG co-treatment can induce the expression of NRF2-downstream target genes such as that of heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1). A small interfering RNA study revealed that the knockdown of NRF2 can abrogate NG-mediated protection of the cells from PQ-induced cellular toxicity. We propose that NG effectively alleviates PQ-induced cytotoxicity in human bronchial epithelial BEAS-2B cells through the NRF2-regulated antioxidant defense pathway, and NG might be a good therapeutic candidate molecule in oxidative stress-related diseases.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisher한국미생물·생명공학회-
dc.titleNaringenin Exerts Cytoprotective Effect Against Paraquat-Induced Toxicity in Human Bronchial Epithelial BEAS-2B Cells Through NRF2 Activation-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.4014/jmb.1402.02001-
dc.identifier.scopusid2-s2.0-84901014569-
dc.identifier.wosid000336511400004-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, v.24, no.5, pp 605 - 613-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.volume24-
dc.citation.number5-
dc.citation.startPage605-
dc.citation.endPage613-
dc.type.docTypeArticle-
dc.identifier.kciidART001877654-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalResearchAreaMicrobiology-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryMicrobiology-
dc.subject.keywordPlusTRANSCRIPTION FACTOR NRF2-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusANTIOXIDANTS-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusFLAVONOIDS-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusTARGET-
dc.subject.keywordPlusGENES-
dc.subject.keywordAuthorNaringenin-
dc.subject.keywordAuthorparaquat-
dc.subject.keywordAuthorantioxidant-related genes-
dc.subject.keywordAuthorhuman bronchial epithelial BEAS-2B cells-
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