Clinical characteristics of Graves' orbitopathy in patients showing discrepancy between levels from TBII assays and TSI bioassay
DC Field | Value | Language |
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dc.contributor.author | Jang, Sun Young | - |
dc.contributor.author | Shin, Dong Yeob | - |
dc.contributor.author | Lee, Eun Jig | - |
dc.contributor.author | Yoon, Jin Sook | - |
dc.date.accessioned | 2021-08-11T22:47:25Z | - |
dc.date.available | 2021-08-11T22:47:25Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.issn | 1365-2265 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12301 | - |
dc.description.abstract | Objective To investigate clinical characteristics of patients with Graves' orbitopathy (GO) who showed discrepancies between levels of thyroid-stimulating immunoglobulin (TSI) and thyrotropin-binding inhibitory immunoglobulin (TBII). Design Comparative case series. Patients A total of 317 patients with GO in whom Mc4-TSI and M22-TRAb (third-generation TBII) were measured simultaneously. Patients were divided into four groups according to TRAb levels as followings: Group 1, TBII and TSI<median value; Group 2, TBII >= median, TSI<median; Group 3, TBII<median, TSI >= median; Group 4, both TBII and TSI >= median. Measurement Endocrine and ophthalmic clinical manifestations in each group. Results The median value of M22-TRAb was 6 center dot 11 IU/l and that of Mc4-TSI was 415 center dot 1 (SRR%). One hundred seventeen patients were classified as Group 1, 41 patients as Group 2, 41 patients as group 3 and 118 patients as group 4. Mean CAS was significantly higher in Groups 3 (2 center dot 2) and 4 (2 center dot 2) than in Groups 1 (1 center dot 6) and 2 (1 center dot 4; P=0 center dot 001, anova). Mean modified NOSPECS scores were significantly higher (P<0 center dot 001, anova) in Groups 3 (4 center dot 1) and 4 (4 center dot 1) than in Groups 1 (3 center dot 1) and 2 (2 center dot 3). The proportion of patients with hyperthyroidism was larger in Group 2 (85 center dot 4% [35/41 patients]) than in Group 3 (48 center dot 8% [20/41 patients]; P=0 center dot 002). Conclusions GO is more active and severe in patients with predominant Mc4-TSI than in patients with predominant M22-TRAb. Patients with hyperthyroidism were more likely to be included with patients with predominant M22-TRAb than with predominant Mc4-TSI. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Clinical characteristics of Graves' orbitopathy in patients showing discrepancy between levels from TBII assays and TSI bioassay | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/cen.12318 | - |
dc.identifier.scopusid | 2-s2.0-84895923522 | - |
dc.identifier.wosid | 000332391000017 | - |
dc.identifier.bibliographicCitation | Clinical Endocrinology, v.80, no.4, pp 591 - 597 | - |
dc.citation.title | Clinical Endocrinology | - |
dc.citation.volume | 80 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 591 | - |
dc.citation.endPage | 597 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | THYROTROPIN RECEPTOR ANTIBODIES | - |
dc.subject.keywordPlus | THYROID-STIMULATING ANTIBODY | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | OPHTHALMOPATHY | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | IMMUNOGLOBULIN | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | FEATURES | - |
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