Encapsulation of simvastatin in PLGA microspheres loaded into hydrogel loaded BCP porous spongy scaffold as a controlled drug delivery system for bone tissue regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nath, Subrata D. | - |
dc.contributor.author | Linh, Nguyen T. B. | - |
dc.contributor.author | Sadiasa, Alexander | - |
dc.contributor.author | Lee, Byong T. | - |
dc.date.accessioned | 2021-08-11T22:47:26Z | - |
dc.date.available | 2021-08-11T22:47:26Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 0885-3282 | - |
dc.identifier.issn | 1530-8022 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12304 | - |
dc.description.abstract | The main objective of this study was to fabricate a controlled drug delivery which is simultaneously effective for bone regeneration. We have encapsulated simvastatin, which enhances osteoblastic activity, in the poly (lactic-co-glycolic acid) microspheres. Loading of these microspheres inside the spongy scaffold of biphasic calcium phosphate with the help of Gelatin (Gel) hydrogel controls the delivery of the drug, and ensures a more favorable drug release profile. As a result, some significant benefits have been achieved, such as higher mechanical strength, excellent biocompatibility in invitro experiments. For determining the characteristics of the composite scaffold, several analysis, such as scanning electron microscope, EDX, X-ray diffraction, FT-IR, and porosity were carried out. The invitro drug release profile clearly indicates that simvastatin release from the microsphere was more controlled and prolonged after loading in the scaffold. Biocompatibility was certainly higher for the final composite scaffold compared to drug unloaded scaffold, as assessed through MTT assay and Confocal imaging with MC3T3-E1 pre-osteoblast cells. Cell attachment and proliferation were certainly higher in the presence of drug loaded microspheres. Bone remodeling gene and protein expression were observed by real-time polymerase chain reaction and Western blot respectively. Simvastatin loaded scaffold exhibited the best results in every determination which was carried out. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE Publications | - |
dc.title | Encapsulation of simvastatin in PLGA microspheres loaded into hydrogel loaded BCP porous spongy scaffold as a controlled drug delivery system for bone tissue regeneration | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1177/0885328213499272 | - |
dc.identifier.scopusid | 2-s2.0-84890151904 | - |
dc.identifier.wosid | 000333399200003 | - |
dc.identifier.bibliographicCitation | Journal of Biomaterials Applications, v.28, no.8, pp 1151 - 1163 | - |
dc.citation.title | Journal of Biomaterials Applications | - |
dc.citation.volume | 28 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1151 | - |
dc.citation.endPage | 1163 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | COMPOSITE SCAFFOLDS | - |
dc.subject.keywordPlus | PORE-SIZE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | NANOSPHERES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CERAMICS | - |
dc.subject.keywordPlus | FRACTURE | - |
dc.subject.keywordPlus | STATINS | - |
dc.subject.keywordAuthor | BCP | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | scaffold | - |
dc.subject.keywordAuthor | Sponge replica | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | simvastatin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.